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- W2079348294 abstract "Chimeric mice were constructed by injection of thymus cells into nu/nu mice. The thymus cells carried a different immunoglobulin (Ig) heavy chain linkage group than the cells of the recipients. The chimeric animals were then immunized with the hapten (4-hydroxy-3-nitro-phenyl)acetyl (NP) on an appropriate carrier, and NP-binding receptor molecules were isolated from the spleen cells of the animals. Receptor molecules and antibodies were analyzed for the presence of two Ig heavy chain variable region (VH) markers which are specific for the anti-NP response of mice carrying the Igb allogroup, namely the NPb idiotpye and the heteroclitic fine specificity of hapten binding. Two types of receptor molecules are obtained by our method, those carrying determinants of Ig constant domains (anti-Ig+ receptors) and others lacking such determinants (anti-Ig− receptors). The two VH region markers were found on anti-Ig− receptors but not on anti-Ig+ receptors and humoral antibodies when the T cells in the chimeric mice carried the Igb allogroup, whereas the B cells were Iga/a. Conversely, anti-Ig+ receptors and humoral antibodies but not anti-Ig−receptors, expressed the two markers when the B cells of the chimeras carried the Igband the T cells the Iga allogroup. From these results and previous data showing that anti-Ig− receptors are enriched together with T lymphocytes and anti-Ig+ receptors together with B cells, we conclude that the VH-bearing anti-Ig− receptors are not only present on T cells, but are indeed synthesized by these cells." @default.
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- W2079348294 date "1979-10-01" @default.
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- W2079348294 title "Isolated hapten-binding receptors of sensitized lymphocytes: V. Cellular origin of receptor molecules" @default.
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- W2079348294 doi "https://doi.org/10.1002/eji.1830091013" @default.
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