FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079348552> ?p ?o ?g. }

• W2079348552 endingPage "1186" @default.
• W2079348552 startingPage "1178" @default.
• W2079348552 abstract "The ubiquitous gram-positive bacterium Staphylococcus aureus occupies a unique niche in humans for its ability to survive both as a commensal and a life-threatening pathogen. Its complex relationship with the host and its ability to engender a throng of virulence factors, have hindered the development of a successful vaccine against it. The use of immunoadjuvants to enhance host immunity and prevent the shift from commensalism to pathogenicity is a rational approach for containing infection. The objective of this study was to understand the mechanisms by which alum and two phytol-derived immunoadjuvants, phytanol (PHIS-01)1 and phytanyl chloride (PCl)2 shape the interaction between S. aureus and its murine host. We studied the effects of the phytol derivatives, relative to alum, on the induction of inflammatory cytokines and chemokines, recruitment of CD11b+ cells, generation of specific anti-S. aureus antibodies and in vitro clearance of S. aureus. Our results showed that both PHIS-01 and PCl were stronger inducers of protective cytokines IL-17 and IL-1β than alum, and far exceeded alum in enhancing anti-S. aureus antibody response. However, both alum and the phytol derivatives (particularly PCl) promoted efficient recruitment of CD11b+ cells. Furthermore, PHIS-01, alum and to a lesser extent, PCl were able to up-regulate the expression of key inflammation-related genes that were highly down-regulated by S. aureus alone. In vitro killing assays showed that both PHIS-01 and PCl were far more potent than alum in promoting S. aureus clearance; this indicated their efficiency in shaping an effective anti-S. aureus immune microenvironment. In summary, our study provides evidence for the better effectiveness of phytol-derived immunoadjuvants over alum in enhancing anti-S. aureus immunity." @default.
• W2079348552 created "2016-06-24" @default.
• W2079348552 creator A5012476636 @default.
• W2079348552 creator A5019527884 @default.
• W2079348552 creator A5070605420 @default.
• W2079348552 date "2013-02-01" @default.
• W2079348552 modified "2023-09-27" @default.
• W2079348552 title "Efficacy of phytol-derived diterpenoid immunoadjuvants over alum in shaping the murine host's immune response to Staphylococcus aureus" @default.
• W2079348552 cites W1525571716 @default.
• W2079348552 cites W1664996601 @default.
• W2079348552 cites W1763873242 @default.
• W2079348552 cites W1937290251 @default.
• W2079348552 cites W1972318912 @default.
• W2079348552 cites W1979195886 @default.
• W2079348552 cites W1981243375 @default.
• W2079348552 cites W1982490464 @default.
• W2079348552 cites W1987671154 @default.
• W2079348552 cites W1989527030 @default.
• W2079348552 cites W1991323622 @default.
• W2079348552 cites W1999481547 @default.
• W2079348552 cites W2003788503 @default.
• W2079348552 cites W2008508169 @default.
• W2079348552 cites W2011370331 @default.
• W2079348552 cites W2019899829 @default.
• W2079348552 cites W2028145763 @default.
• W2079348552 cites W2038324419 @default.
• W2079348552 cites W2042365977 @default.
• W2079348552 cites W2042728718 @default.
• W2079348552 cites W2043165163 @default.
• W2079348552 cites W2067523074 @default.
• W2079348552 cites W2078504495 @default.
• W2079348552 cites W2084783722 @default.
• W2079348552 cites W2089835817 @default.
• W2079348552 cites W2090697609 @default.
• W2079348552 cites W2092778039 @default.
• W2079348552 cites W2094613194 @default.
• W2079348552 cites W2103851091 @default.
• W2079348552 cites W2111157195 @default.
• W2079348552 cites W2121729767 @default.
• W2079348552 cites W2121828560 @default.
• W2079348552 cites W2125682786 @default.
• W2079348552 cites W2130196278 @default.
• W2079348552 cites W2131757598 @default.
• W2079348552 cites W2137019479 @default.
• W2079348552 cites W2138769717 @default.
• W2079348552 cites W2140013081 @default.
• W2079348552 cites W2142495846 @default.
• W2079348552 cites W2147249830 @default.
• W2079348552 cites W2148341270 @default.
• W2079348552 cites W2149794110 @default.
• W2079348552 cites W2161524185 @default.
• W2079348552 cites W2163206714 @default.
• W2079348552 cites W2166504245 @default.
• W2079348552 cites W4242426124 @default.
• W2079348552 cites W4249692247 @default.
• W2079348552 cites W4251889696 @default.
• W2079348552 doi "https://doi.org/10.1016/j.vaccine.2012.12.069" @default.
• W2079348552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23313815" @default.
• W2079348552 hasPublicationYear "2013" @default.
• W2079348552 type Work @default.
• W2079348552 sameAs 2079348552 @default.
• W2079348552 citedByCount "10" @default.
• W2079348552 countsByYear W20793485522014 @default.
• W2079348552 countsByYear W20793485522015 @default.
• W2079348552 countsByYear W20793485522016 @default.
• W2079348552 countsByYear W20793485522018 @default.
• W2079348552 countsByYear W20793485522019 @default.
• W2079348552 countsByYear W20793485522021 @default.
• W2079348552 countsByYear W20793485522022 @default.
• W2079348552 crossrefType "journal-article" @default.
• W2079348552 hasAuthorship W2079348552A5012476636 @default.
• W2079348552 hasAuthorship W2079348552A5019527884 @default.
• W2079348552 hasAuthorship W2079348552A5070605420 @default.
• W2079348552 hasConcept C159654299 @default.
• W2079348552 hasConcept C178790620 @default.
• W2079348552 hasConcept C185592680 @default.
• W2079348552 hasConcept C203014093 @default.
• W2079348552 hasConcept C2776593056 @default.
• W2079348552 hasConcept C2779489039 @default.
• W2079348552 hasConcept C2780924562 @default.
• W2079348552 hasConcept C523546767 @default.
• W2079348552 hasConcept C54355233 @default.
• W2079348552 hasConcept C55493867 @default.
• W2079348552 hasConcept C86803240 @default.
• W2079348552 hasConcept C8891405 @default.
• W2079348552 hasConcept C89423630 @default.
• W2079348552 hasConceptScore W2079348552C159654299 @default.
• W2079348552 hasConceptScore W2079348552C178790620 @default.
• W2079348552 hasConceptScore W2079348552C185592680 @default.
• W2079348552 hasConceptScore W2079348552C203014093 @default.
• W2079348552 hasConceptScore W2079348552C2776593056 @default.
• W2079348552 hasConceptScore W2079348552C2779489039 @default.
• W2079348552 hasConceptScore W2079348552C2780924562 @default.
• W2079348552 hasConceptScore W2079348552C523546767 @default.
• W2079348552 hasConceptScore W2079348552C54355233 @default.
• W2079348552 hasConceptScore W2079348552C55493867 @default.
• W2079348552 hasConceptScore W2079348552C86803240 @default.
• W2079348552 hasConceptScore W2079348552C8891405 @default.

• next