FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079348811> ?p ?o ?g. }

• W2079348811 endingPage "587" @default.
• W2079348811 startingPage "579" @default.
• W2079348811 abstract "OBJECTIVE: Previous studies demonstrated that activation of receptor tyrosine kinases in human meningiomas by an autocrine or paracrine growth-stimulatory loop plays an important role in meningioma proliferation. Although it is well established that the proliferative signal from protein tyrosine kinase receptors is transduced through Ras proteins, the relevance of the Ras pathway in meningioma proliferation, to our knowledge, has not been studied. The purpose of this study was, therefore, to determine whether Ras proteins are functionally important in meningioma proliferation. METHODS: Meningioma cells of nine primary cell cultures were infected with the recombinant adenovirus Ad-rasN17 encoding the dominant negative Ras protein or control adenovirus Ad-pAC. Ras-N17 is a Ras mutant protein with substitution of asparagine for serine at position 17 in the cellular Ha-Ras protein that inhibits function of all endogenous cellular Ras proteins. Proliferation of meningioma cells was measured using [3H]thymidine of 5-bromo-2'-deoxyuridine labeling and detection assays. RESULTS: Infection of meningioma cells with Ad-rasN17 dramatically increased the expression levels of the Ras-N17 mutant protein and inhibited phosphorylation of the mitogen-activated protein kinases, compared with uninfected cells or cells infected with the control adenovirus. Suppression of Ras proteins inhibited proliferation of all exponentially growing and growth-arrested meningioma cells stimulated with serum. CONCLUSION: The obtained results suggest that proliferation of primary meningioma cells is dependent on the presence of functional Ras proteins. Therefore, inhibition of the Ras pathway may be important in preventing growth factor-stimulated meningioma proliferation." @default.
• W2079348811 created "2016-06-24" @default.
• W2079348811 creator A5015090263 @default.
• W2079348811 creator A5022325052 @default.
• W2079348811 creator A5034994901 @default.
• W2079348811 creator A5056744531 @default.
• W2079348811 creator A5069905380 @default.
• W2079348811 creator A5087729622 @default.
• W2079348811 date "1999-03-01" @default.
• W2079348811 modified "2023-10-02" @default.
• W2079348811 title "Adenovirus-mediated Gene Transfer of Dominant Negative Ha-Ras Inhibits Proliferation of Primary Meningioma Cells" @default.
• W2079348811 cites W1495670687 @default.
• W2079348811 cites W1868956420 @default.
• W2079348811 cites W1909400967 @default.
• W2079348811 cites W1966081096 @default.
• W2079348811 cites W1976451653 @default.
• W2079348811 cites W1984537869 @default.
• W2079348811 cites W1990028805 @default.
• W2079348811 cites W1991760443 @default.
• W2079348811 cites W1995198169 @default.
• W2079348811 cites W2001895687 @default.
• W2079348811 cites W2025931329 @default.
• W2079348811 cites W2041106214 @default.
• W2079348811 cites W2049128935 @default.
• W2079348811 cites W2053642340 @default.
• W2079348811 cites W2062427243 @default.
• W2079348811 cites W2086159524 @default.
• W2079348811 cites W2107666634 @default.
• W2079348811 cites W2117669008 @default.
• W2079348811 cites W2162499001 @default.
• W2079348811 cites W2173344695 @default.
• W2079348811 cites W2176636090 @default.
• W2079348811 cites W2317865573 @default.
• W2079348811 cites W2322386893 @default.
• W2079348811 cites W4256715725 @default.
• W2079348811 cites W4292820908 @default.
• W2079348811 cites W988054948 @default.
• W2079348811 doi "https://doi.org/10.1097/00006123-199903000-00080" @default.
• W2079348811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10069595" @default.
• W2079348811 hasPublicationYear "1999" @default.
• W2079348811 type Work @default.
• W2079348811 sameAs 2079348811 @default.
• W2079348811 citedByCount "34" @default.
• W2079348811 countsByYear W20793488112012 @default.
• W2079348811 countsByYear W20793488112013 @default.
• W2079348811 countsByYear W20793488112015 @default.
• W2079348811 countsByYear W20793488112016 @default.
• W2079348811 countsByYear W20793488112019 @default.
• W2079348811 countsByYear W20793488112022 @default.
• W2079348811 countsByYear W20793488112023 @default.
• W2079348811 crossrefType "journal-article" @default.
• W2079348811 hasAuthorship W2079348811A5015090263 @default.
• W2079348811 hasAuthorship W2079348811A5022325052 @default.
• W2079348811 hasAuthorship W2079348811A5034994901 @default.
• W2079348811 hasAuthorship W2079348811A5056744531 @default.
• W2079348811 hasAuthorship W2079348811A5069905380 @default.
• W2079348811 hasAuthorship W2079348811A5087729622 @default.
• W2079348811 hasConcept C101544691 @default.
• W2079348811 hasConcept C142724271 @default.
• W2079348811 hasConcept C153911025 @default.
• W2079348811 hasConcept C2777553839 @default.
• W2079348811 hasConcept C2779160599 @default.
• W2079348811 hasConcept C2780045450 @default.
• W2079348811 hasConcept C502942594 @default.
• W2079348811 hasConcept C55493867 @default.
• W2079348811 hasConcept C57074206 @default.
• W2079348811 hasConcept C62112901 @default.
• W2079348811 hasConcept C62478195 @default.
• W2079348811 hasConcept C71924100 @default.
• W2079348811 hasConcept C86803240 @default.
• W2079348811 hasConcept C95444343 @default.
• W2079348811 hasConceptScore W2079348811C101544691 @default.
• W2079348811 hasConceptScore W2079348811C142724271 @default.
• W2079348811 hasConceptScore W2079348811C153911025 @default.
• W2079348811 hasConceptScore W2079348811C2777553839 @default.
• W2079348811 hasConceptScore W2079348811C2779160599 @default.
• W2079348811 hasConceptScore W2079348811C2780045450 @default.
• W2079348811 hasConceptScore W2079348811C502942594 @default.
• W2079348811 hasConceptScore W2079348811C55493867 @default.
• W2079348811 hasConceptScore W2079348811C57074206 @default.
• W2079348811 hasConceptScore W2079348811C62112901 @default.
• W2079348811 hasConceptScore W2079348811C62478195 @default.
• W2079348811 hasConceptScore W2079348811C71924100 @default.
• W2079348811 hasConceptScore W2079348811C86803240 @default.
• W2079348811 hasConceptScore W2079348811C95444343 @default.
• W2079348811 hasIssue "3" @default.
• W2079348811 hasLocation W20793488111 @default.
• W2079348811 hasLocation W20793488112 @default.
• W2079348811 hasOpenAccess W2079348811 @default.
• W2079348811 hasPrimaryLocation W20793488111 @default.
• W2079348811 hasRelatedWork W1832041093 @default.
• W2079348811 hasRelatedWork W2004726042 @default.
• W2079348811 hasRelatedWork W2067282472 @default.
• W2079348811 hasRelatedWork W2081958146 @default.
• W2079348811 hasRelatedWork W2160253516 @default.
• W2079348811 hasRelatedWork W2381340599 @default.
• W2079348811 hasRelatedWork W2384817912 @default.
• W2079348811 hasRelatedWork W2462039273 @default.

• next