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• W2079352867 startingPage "173" @default.
• W2079352867 abstract "The fact that the allele epsilon 4 of the Apolipoprotein E (APOE) gene could act like a risk factor not only in late-onset familial and sporadic Alzheimer's disease (AD) but also in cerebrovascular disease (CVD) and vascular dementia (VaD) is still controversial.In order to study if epsilon 4 allele is overrepresented not only in AD but also in CVD and VaD, APOE genotyping was undertaken in a series of 247 patients: 26 cases with VaD, 41 cases with CVD but without cognitive impairment (CVD-C), 83 cases with AD and 97 aged-matched healthy controls (HC).Percentages of subjects bearing one or two copies of the epsilon 4 allele was much higher in AD patients (54%) than in either CVD-C (29%) (p<0.05), VaD (15%) (p<0.001) or HC (13%) (p<0.001).These results strengthen the hypothesis that involves the APOE epsilon 4 allele as a predisposing factor for AD, but not for CVD or VaD." @default.
• W2079352867 created "2016-06-24" @default.
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• W2079352867 date "2002-11-01" @default.
• W2079352867 modified "2023-10-17" @default.
• W2079352867 title "APOE genotype in cerebrovascular disease and vascular dementia" @default.
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• W2079352867 doi "https://doi.org/10.1016/s0022-510x(02)00286-1" @default.
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• W2079352867 hasPublicationYear "2002" @default.
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