FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079353005> ?p ?o ?g. }

• W2079353005 endingPage "1037" @default.
• W2079353005 startingPage "1027" @default.
• W2079353005 abstract "1 The effects of the benzopyran K-channel opener, BRL55834, on mechanical activity in bovine trachealis and rat portal vein were studied together with membrane currents in freshly-isolated single cells derived from these tissues. 2 BRL55834 (3nM-l μm) produced a concentration-dependent relaxation of bovine trachealis precontracted with 100 μm histamine and reduced the spontaneous mechanical activity of rat portal veins, effects which were antagonized by glibenclamide (1–10 μm) but were not reversible on washing. In contrast, charybdotoxin (250 nM) did not modify the spasmolytic effect of BRL55834 in bovine trachealis. 3 BRL55834 (10 nM-10 μm) did not relax segments of bovine trachealis precontracted with 80 mM KC1. 4 In some freshly-isolated single cells from bovine trachealis held at −10 mV, BRL55834 (3 μm) induced a time-independent outward K-current which was partially resistant to inhibition by glibenclamide (10 μm). In other cells, a very noisy, outwardly-rectifying and charybdotoxin-sensitive current developed in the presence of BRL55834 (3 μm) and in time-matched control cells. 5 In freshly-isolated single cells from rat portal vein held at −10 mV, BRL55834 (3 μm) induced a time-and calcium-independent outward K-current which was partially resistant (approximately 25% inhibition at +40 mV) to subsequent inhibition by glibenclamide (10 um). In contrast, levcromakalim induced a time-independent outward K-current which was completely inhibited by glibenclamide 10 μm. 6 With the non-hydrolysable ATP analogue, AMP-PCP (5 mM), in the pipette, the ability of BRL55834 to induce a time-independent K-current in portal vein cells was markedly reduced (approximately 80% inhibition at +40 mV) whereas the effects of 10 um levcromakalim were totally inhibited. 7 The glibenclamide-resistant current component induced by BRL55834 was totally inhibited by phentolamine (100 μm), a concentration that had no effect on the peak current (IBK(Ca)) induced by NS1619 (33 μm). 8 Stationary fluctuation analysis of the noise associated with the glibenclamide-insensitive K-current induced by BRL55834 in rat portal vein cells indicated that the unitary current flowing through the underlying channels was 0.26 pA at −10 mV, a value inconsistent with the involvement of BKca. 9 It is concluded that the relaxations of both bovine trachea and rat portal vein produced by BRL55834 are associated with the opening of K-channels. These are probably identical to the ATP-sensitive K-channel opened by levcromakalim, although the involvement of an additional K-channel cannot be excluded. The reduced sensitivity of the BRL55834-induced changes to glibenclamide and to AMP-PCP may result from avid binding of BRL55834 to its site of action." @default.
• W2079353005 created "2016-06-24" @default.
• W2079353005 creator A5045900735 @default.
• W2079353005 creator A5070697806 @default.
• W2079353005 creator A5079898786 @default.
• W2079353005 creator A5083787772 @default.
• W2079353005 creator A5088584936 @default.
• W2079353005 date "1995-07-01" @default.
• W2079353005 modified "2023-09-27" @default.
• W2079353005 title "Effects of BRL55834 in rat portal vein and bovine trachea: evidence for the induction of a glibenclamide-resistant, ATP-sensitive potassium current" @default.
• W2079353005 cites W1156084614 @default.
• W2079353005 cites W1561306503 @default.
• W2079353005 cites W1973025303 @default.
• W2079353005 cites W1973182414 @default.
• W2079353005 cites W1976526326 @default.
• W2079353005 cites W1989438601 @default.
• W2079353005 cites W1993476421 @default.
• W2079353005 cites W1995344929 @default.
• W2079353005 cites W1997511216 @default.
• W2079353005 cites W1999398321 @default.
• W2079353005 cites W2000138794 @default.
• W2079353005 cites W2002920360 @default.
• W2079353005 cites W2004295520 @default.
• W2079353005 cites W2009667219 @default.
• W2079353005 cites W2015061965 @default.
• W2079353005 cites W2015426350 @default.
• W2079353005 cites W2022945740 @default.
• W2079353005 cites W2044437180 @default.
• W2079353005 cites W2046433412 @default.
• W2079353005 cites W2053130739 @default.
• W2079353005 cites W2063840208 @default.
• W2079353005 cites W2068319484 @default.
• W2079353005 cites W2082444334 @default.
• W2079353005 cites W2089017203 @default.
• W2079353005 cites W2090405680 @default.
• W2079353005 cites W2093869524 @default.
• W2079353005 cites W2116963442 @default.
• W2079353005 cites W2148255642 @default.
• W2079353005 cites W2161540449 @default.
• W2079353005 cites W2171819148 @default.
• W2079353005 cites W2172079625 @default.
• W2079353005 cites W2409144171 @default.
• W2079353005 cites W4235167903 @default.
• W2079353005 doi "https://doi.org/10.1111/j.1476-5381.1995.tb15914.x" @default.
• W2079353005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1909032" @default.
• W2079353005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7582499" @default.
• W2079353005 hasPublicationYear "1995" @default.
• W2079353005 type Work @default.
• W2079353005 sameAs 2079353005 @default.
• W2079353005 citedByCount "4" @default.
• W2079353005 crossrefType "journal-article" @default.
• W2079353005 hasAuthorship W2079353005A5045900735 @default.
• W2079353005 hasAuthorship W2079353005A5070697806 @default.
• W2079353005 hasAuthorship W2079353005A5079898786 @default.
• W2079353005 hasAuthorship W2079353005A5083787772 @default.
• W2079353005 hasAuthorship W2079353005A5088584936 @default.
• W2079353005 hasBestOaLocation W20793530051 @default.
• W2079353005 hasConcept C12554922 @default.
• W2079353005 hasConcept C126322002 @default.
• W2079353005 hasConcept C134018914 @default.
• W2079353005 hasConcept C147944092 @default.
• W2079353005 hasConcept C170493617 @default.
• W2079353005 hasConcept C178790620 @default.
• W2079353005 hasConcept C181911157 @default.
• W2079353005 hasConcept C185592680 @default.
• W2079353005 hasConcept C202870285 @default.
• W2079353005 hasConcept C2776919887 @default.
• W2079353005 hasConcept C2778457506 @default.
• W2079353005 hasConcept C2779411790 @default.
• W2079353005 hasConcept C2779768347 @default.
• W2079353005 hasConcept C2780419564 @default.
• W2079353005 hasConcept C2781295685 @default.
• W2079353005 hasConcept C517785266 @default.
• W2079353005 hasConcept C55493867 @default.
• W2079353005 hasConcept C555293320 @default.
• W2079353005 hasConcept C71924100 @default.
• W2079353005 hasConcept C83743174 @default.
• W2079353005 hasConcept C86803240 @default.
• W2079353005 hasConcept C98274493 @default.
• W2079353005 hasConceptScore W2079353005C12554922 @default.
• W2079353005 hasConceptScore W2079353005C126322002 @default.
• W2079353005 hasConceptScore W2079353005C134018914 @default.
• W2079353005 hasConceptScore W2079353005C147944092 @default.
• W2079353005 hasConceptScore W2079353005C170493617 @default.
• W2079353005 hasConceptScore W2079353005C178790620 @default.
• W2079353005 hasConceptScore W2079353005C181911157 @default.
• W2079353005 hasConceptScore W2079353005C185592680 @default.
• W2079353005 hasConceptScore W2079353005C202870285 @default.
• W2079353005 hasConceptScore W2079353005C2776919887 @default.
• W2079353005 hasConceptScore W2079353005C2778457506 @default.
• W2079353005 hasConceptScore W2079353005C2779411790 @default.
• W2079353005 hasConceptScore W2079353005C2779768347 @default.
• W2079353005 hasConceptScore W2079353005C2780419564 @default.
• W2079353005 hasConceptScore W2079353005C2781295685 @default.
• W2079353005 hasConceptScore W2079353005C517785266 @default.
• W2079353005 hasConceptScore W2079353005C55493867 @default.
• W2079353005 hasConceptScore W2079353005C555293320 @default.
• W2079353005 hasConceptScore W2079353005C71924100 @default.

• next