FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079353552> ?p ?o ?g. }

• W2079353552 endingPage "266" @default.
• W2079353552 startingPage "262" @default.
• W2079353552 abstract "Background: The observation of a familial accumulation of ductal pancreatic adenocarcinoma (PC) and the increased risk for PC in certain hereditary tumor syndromes point to a genetic predisposition for PC. In order to evaluate the characteristics of familial PC, a German national case collection for familial pancreas cancer (FaPaCa) was established. Patients and Methods: In FaPaCa, families of patients with PC are being collected, who have at least 1 first-degree relative with PC or with malignant melanoma. Histopathologic verification of tumor diagnoses, acquisition of clinical data, and full genetic counselling are prerequisites for the enrollment of PC families in FaPaCa. Results: So far, 21 families fulfilled the criteria for partaking in FaPaCa. In 11 families, PC represented the sole tumor entity. Additional tumors included malignant melanoma in 5, breast cancer in 3, and prostatic, colon or lung cancer in 2 families. Compared to the preceding generation, a younger age at diagnosis of PC was observed in the offspring of PC patients (offspring median 53 years vs. parents median 75.5 years). Conclusion: The association of PC and breast cancer, and of PC and malignant melanoma suggests predisposing mutations in the BRCA2 or CDKN2A genes in about one third of the FaPaCa families. Mutational analyses in both candidate genes may help to identify individuals who are at an increased risk for developing PC. A shift towards a younger age at diagnosis in our PC families may indicate genetic anticipation and/or changes of patterns of exogenous risk factors." @default.
• W2079353552 created "2016-06-24" @default.
• W2079353552 creator A5000633602 @default.
• W2079353552 creator A5006706914 @default.
• W2079353552 creator A5008757972 @default.
• W2079353552 creator A5023222243 @default.
• W2079353552 creator A5039626163 @default.
• W2079353552 creator A5039759897 @default.
• W2079353552 creator A5045306100 @default.
• W2079353552 creator A5065236534 @default.
• W2079353552 creator A5074633455 @default.
• W2079353552 creator A5075619290 @default.
• W2079353552 creator A5078129375 @default.
• W2079353552 creator A5089879417 @default.
• W2079353552 creator A5090061866 @default.
• W2079353552 date "2002-01-01" @default.
• W2079353552 modified "2023-09-29" @default.
• W2079353552 title "German National Case Collection of Familial Pancreatic Cancer – Clinical-Genetic Analysis of the First 21 Families" @default.
• W2079353552 cites W1560231616 @default.
• W2079353552 cites W1579263702 @default.
• W2079353552 cites W1785779992 @default.
• W2079353552 cites W1909128047 @default.
• W2079353552 cites W1964254902 @default.
• W2079353552 cites W1967370147 @default.
• W2079353552 cites W1972179578 @default.
• W2079353552 cites W1974584607 @default.
• W2079353552 cites W1978151850 @default.
• W2079353552 cites W1985449334 @default.
• W2079353552 cites W1986293030 @default.
• W2079353552 cites W2000953353 @default.
• W2079353552 cites W2034960814 @default.
• W2079353552 cites W2036049436 @default.
• W2079353552 cites W2045901590 @default.
• W2079353552 cites W2049488969 @default.
• W2079353552 cites W2050164769 @default.
• W2079353552 cites W2054214724 @default.
• W2079353552 cites W2070736199 @default.
• W2079353552 cites W2078180252 @default.
• W2079353552 cites W2089834401 @default.
• W2079353552 cites W2133282020 @default.
• W2079353552 cites W2150207805 @default.
• W2079353552 cites W2169482850 @default.
• W2079353552 cites W2171667490 @default.
• W2079353552 cites W2325799791 @default.
• W2079353552 cites W2404160391 @default.
• W2079353552 cites W2469402420 @default.
• W2079353552 cites W2593526662 @default.
• W2079353552 cites W2041253030 @default.
• W2079353552 cites W2337230273 @default.
• W2079353552 doi "https://doi.org/10.1159/000064320" @default.
• W2079353552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12119461" @default.
• W2079353552 hasPublicationYear "2002" @default.
• W2079353552 type Work @default.
• W2079353552 sameAs 2079353552 @default.
• W2079353552 citedByCount "22" @default.
• W2079353552 countsByYear W20793535522012 @default.
• W2079353552 countsByYear W20793535522015 @default.
• W2079353552 countsByYear W20793535522018 @default.
• W2079353552 countsByYear W20793535522023 @default.
• W2079353552 crossrefType "journal-article" @default.
• W2079353552 hasAuthorship W2079353552A5000633602 @default.
• W2079353552 hasAuthorship W2079353552A5006706914 @default.
• W2079353552 hasAuthorship W2079353552A5008757972 @default.
• W2079353552 hasAuthorship W2079353552A5023222243 @default.
• W2079353552 hasAuthorship W2079353552A5039626163 @default.
• W2079353552 hasAuthorship W2079353552A5039759897 @default.
• W2079353552 hasAuthorship W2079353552A5045306100 @default.
• W2079353552 hasAuthorship W2079353552A5065236534 @default.
• W2079353552 hasAuthorship W2079353552A5074633455 @default.
• W2079353552 hasAuthorship W2079353552A5075619290 @default.
• W2079353552 hasAuthorship W2079353552A5078129375 @default.
• W2079353552 hasAuthorship W2079353552A5089879417 @default.
• W2079353552 hasAuthorship W2079353552A5090061866 @default.
• W2079353552 hasConcept C112672928 @default.
• W2079353552 hasConcept C121608353 @default.
• W2079353552 hasConcept C126322002 @default.
• W2079353552 hasConcept C143998085 @default.
• W2079353552 hasConcept C181199279 @default.
• W2079353552 hasConcept C2776382852 @default.
• W2079353552 hasConcept C2777658100 @default.
• W2079353552 hasConcept C2779234561 @default.
• W2079353552 hasConcept C2780210213 @default.
• W2079353552 hasConcept C2780265364 @default.
• W2079353552 hasConcept C2780340462 @default.
• W2079353552 hasConcept C2781179581 @default.
• W2079353552 hasConcept C2781286802 @default.
• W2079353552 hasConcept C502942594 @default.
• W2079353552 hasConcept C526805850 @default.
• W2079353552 hasConcept C530470458 @default.
• W2079353552 hasConcept C54355233 @default.
• W2079353552 hasConcept C55493867 @default.
• W2079353552 hasConcept C71924100 @default.
• W2079353552 hasConcept C80227256 @default.
• W2079353552 hasConcept C86803240 @default.
• W2079353552 hasConceptScore W2079353552C112672928 @default.
• W2079353552 hasConceptScore W2079353552C121608353 @default.
• W2079353552 hasConceptScore W2079353552C126322002 @default.
• W2079353552 hasConceptScore W2079353552C143998085 @default.

• next