Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079353985> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2079353985 abstract "Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FLBackground: DNA methylation of gene promoters have been show to play a role in the pathogenesis of acute myeloid leukemia. We present in this study a preliminary report of the methylation status of MLH1, p16 and SOCS1 in Puertorrican patients with acute myeloid leukemiaMethods: Peripheral blood was obtained from 24 patients with diagnosis of acute myeloid leukemia before their induction treatments. DNA was isolated and further modified with sodium bisulfite. Methylation-specific polymerase (MSP) chain reaction was performed to detect aberrant promoter methylation of MLH1, p16 and SOCS1.Results: A total of 24 samples were analyzed. The mean age was 49 years (range 22-71) with 17/24 patients younger than 60 years (71%). Most of the patients were female (13/24, 54%). Six patients had diploid cytogenetics (25%), 6 had low risk cytogenetics (25%) and 12 had high risk cytogenetics (50%). Fifteen patients were de Novo AML (63%). Nine patients (38%) presented with WBC counts higher than 10 × 109/L. Thirteen patients (54%) achieved a complete response at the end of the induction therapy. Methylation of MLH1 was detected in 3/24 patients (13%). Methylation of p16 was detected in 5/24 patients (21%). Methylation of SOCS1 was detected in 2/24 patients (8%).Conclusions: A tendency toward an association of methylated p16 with treatment resistance was noted. Also, methylation of SOCS1 was more common among relapsed AML patients. No correlation between methylated MLH1 gene and clinicopathological characteristics was noted. Collection of more patient's samples and correlation with clinical data and patient's ultimate outcome is ongoing.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2766. doi:10.1158/1538-7445.AM2011-2766" @default.
- W2079353985 created "2016-06-24" @default.
- W2079353985 creator A5006711658 @default.
- W2079353985 creator A5031134829 @default.
- W2079353985 creator A5033112544 @default.
- W2079353985 creator A5041149866 @default.
- W2079353985 creator A5042616997 @default.
- W2079353985 creator A5075829483 @default.
- W2079353985 creator A5078157184 @default.
- W2079353985 date "2011-04-15" @default.
- W2079353985 modified "2023-10-17" @default.
- W2079353985 title "Abstract 2766: DNA methylation status of MLH1, p16 and SOCS1 in Puerto Rican patients with acute myeloid leukemia" @default.
- W2079353985 doi "https://doi.org/10.1158/1538-7445.am2011-2766" @default.
- W2079353985 hasPublicationYear "2011" @default.
- W2079353985 type Work @default.
- W2079353985 sameAs 2079353985 @default.
- W2079353985 citedByCount "0" @default.
- W2079353985 crossrefType "proceedings-article" @default.
- W2079353985 hasAuthorship W2079353985A5006711658 @default.
- W2079353985 hasAuthorship W2079353985A5031134829 @default.
- W2079353985 hasAuthorship W2079353985A5033112544 @default.
- W2079353985 hasAuthorship W2079353985A5041149866 @default.
- W2079353985 hasAuthorship W2079353985A5042616997 @default.
- W2079353985 hasAuthorship W2079353985A5075829483 @default.
- W2079353985 hasAuthorship W2079353985A5078157184 @default.
- W2079353985 hasConcept C104317684 @default.
- W2079353985 hasConcept C111425858 @default.
- W2079353985 hasConcept C121608353 @default.
- W2079353985 hasConcept C126322002 @default.
- W2079353985 hasConcept C143998085 @default.
- W2079353985 hasConcept C150194340 @default.
- W2079353985 hasConcept C153911025 @default.
- W2079353985 hasConcept C190727270 @default.
- W2079353985 hasConcept C2776863199 @default.
- W2079353985 hasConcept C2778461978 @default.
- W2079353985 hasConcept C2778729363 @default.
- W2079353985 hasConcept C33288867 @default.
- W2079353985 hasConcept C502942594 @default.
- W2079353985 hasConcept C526805850 @default.
- W2079353985 hasConcept C54355233 @default.
- W2079353985 hasConcept C60748783 @default.
- W2079353985 hasConcept C71924100 @default.
- W2079353985 hasConcept C86803240 @default.
- W2079353985 hasConcept C90924648 @default.
- W2079353985 hasConceptScore W2079353985C104317684 @default.
- W2079353985 hasConceptScore W2079353985C111425858 @default.
- W2079353985 hasConceptScore W2079353985C121608353 @default.
- W2079353985 hasConceptScore W2079353985C126322002 @default.
- W2079353985 hasConceptScore W2079353985C143998085 @default.
- W2079353985 hasConceptScore W2079353985C150194340 @default.
- W2079353985 hasConceptScore W2079353985C153911025 @default.
- W2079353985 hasConceptScore W2079353985C190727270 @default.
- W2079353985 hasConceptScore W2079353985C2776863199 @default.
- W2079353985 hasConceptScore W2079353985C2778461978 @default.
- W2079353985 hasConceptScore W2079353985C2778729363 @default.
- W2079353985 hasConceptScore W2079353985C33288867 @default.
- W2079353985 hasConceptScore W2079353985C502942594 @default.
- W2079353985 hasConceptScore W2079353985C526805850 @default.
- W2079353985 hasConceptScore W2079353985C54355233 @default.
- W2079353985 hasConceptScore W2079353985C60748783 @default.
- W2079353985 hasConceptScore W2079353985C71924100 @default.
- W2079353985 hasConceptScore W2079353985C86803240 @default.
- W2079353985 hasConceptScore W2079353985C90924648 @default.
- W2079353985 hasLocation W20793539851 @default.
- W2079353985 hasOpenAccess W2079353985 @default.
- W2079353985 hasPrimaryLocation W20793539851 @default.
- W2079353985 hasRelatedWork W1432359453 @default.
- W2079353985 hasRelatedWork W1650377924 @default.
- W2079353985 hasRelatedWork W2001343610 @default.
- W2079353985 hasRelatedWork W2002877558 @default.
- W2079353985 hasRelatedWork W2056707782 @default.
- W2079353985 hasRelatedWork W2060604305 @default.
- W2079353985 hasRelatedWork W2066983641 @default.
- W2079353985 hasRelatedWork W2071324817 @default.
- W2079353985 hasRelatedWork W2077690242 @default.
- W2079353985 hasRelatedWork W2112231199 @default.
- W2079353985 hasRelatedWork W2170523029 @default.
- W2079353985 hasRelatedWork W2234019300 @default.
- W2079353985 hasRelatedWork W2323730473 @default.
- W2079353985 hasRelatedWork W2339385299 @default.
- W2079353985 hasRelatedWork W2731374555 @default.
- W2079353985 hasRelatedWork W2943994584 @default.
- W2079353985 hasRelatedWork W3003450803 @default.
- W2079353985 hasRelatedWork W3082566725 @default.
- W2079353985 hasRelatedWork W3133145906 @default.
- W2079353985 hasRelatedWork W2152263808 @default.
- W2079353985 isParatext "false" @default.
- W2079353985 isRetracted "false" @default.
- W2079353985 magId "2079353985" @default.
- W2079353985 workType "article" @default.