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• W2079354768 abstract "Nasal corticosteroids improve polysomnography indices but not symptoms in children with mild to moderate sleep-disordered breathing. We hypothesized that administration of nasal corticosteroids for 4 weeks to snoring children with only mild elevation in their apnea-hypopnea index would improve both polysomnography findings and symptoms of sleep-disordered breathing. Budesonide 50 mcg per nostril twice daily was administered for 4 weeks to children (2–14 years old) with habitual snoring and an apnea-hypopnea index of 1–10 episodes/hr. Subjects were evaluated before treatment and at 2 weeks and 9 months after its completion. Primary outcome variables were changes in apnea-hypopnea index and symptom score. Twenty-seven children were studied. At 2 weeks, the mean apnea-hypopnea index decreased from 5.2 (±2.2) episodes/hr to 3.2 (±1.5) episodes/hr, and median oxygen desaturation of hemoglobin index fell from 3.1 (0.4–8.2) to 1.9 (0.2–5.4) (P < 0.0001). Mean symptom score was 1.33 (±2.11) at baseline, and decreased to −0.008 (±2.24) at 2 weeks after treatment and to −1.08 (±1.75) at 9 months after treatment (P < 0.05). Four weeks of nasal budesonide improved both polysomnography findings and symptoms in children with mild sleep-disordered breathing. The clinical effect is maintained for several months after treatment. Pediatr Pulmonol. 2004; 38:161–167. © 2004 Wiley-Liss, Inc." @default.
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• W2079354768 date "2004-01-01" @default.
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• W2079354768 title "Nasal corticosteroids for children with snoring" @default.
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• W2079354768 doi "https://doi.org/10.1002/ppul.20079" @default.
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