Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079355263> ?p ?o ?g. }
- W2079355263 endingPage "1014" @default.
- W2079355263 startingPage "1009" @default.
- W2079355263 abstract "Hypercholesterolemia is a common complication of liver transplantation and is a risk factor for cardiovascular disease after renal and heart transplant. The effect of hyperlipidemia after liver transplantation is less certain, but a less favorable outcome is to be expected. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors or statins have proven efficacy in reducing serum cholesterol and mortality from cardiovascular disease in the general population. Early evidence shows that statins are safe and effective in treating hypercholesterolemia after liver transplantation. Studies in cardiovascular disease have shown that statins exhibit beneficial properties independent of lipid-lowering. These include anti-inflammatory effects and improvement in endothelial function. Recently, statins were shown to repress induction of major histocompatibility complex class II complexes by interferon-γ, which in turn suppresses activation of T lymphocytes. Such effects may assume significance when using statins after solid-organ transplants. Pravastatin has been shown to reduce acute rejection after cardiac and renal transplantation and to also reduce natural killer cell cytotoxicity in these populations. It remains to be seen whether statins will demonstrate similar benefits after liver transplantation." @default.
- W2079355263 created "2016-06-24" @default.
- W2079355263 creator A5011590009 @default.
- W2079355263 date "2001-12-01" @default.
- W2079355263 modified "2023-10-15" @default.
- W2079355263 title "Can the potential benefits of statins in general medical practice be extrapolated to liver transplantation?" @default.
- W2079355263 cites W1499548788 @default.
- W2079355263 cites W1525331105 @default.
- W2079355263 cites W1939259427 @default.
- W2079355263 cites W1968144530 @default.
- W2079355263 cites W1971163980 @default.
- W2079355263 cites W1977429372 @default.
- W2079355263 cites W1986757474 @default.
- W2079355263 cites W1986898717 @default.
- W2079355263 cites W1996764051 @default.
- W2079355263 cites W1999130484 @default.
- W2079355263 cites W1999869812 @default.
- W2079355263 cites W2001285551 @default.
- W2079355263 cites W2004217456 @default.
- W2079355263 cites W2005529837 @default.
- W2079355263 cites W2008188351 @default.
- W2079355263 cites W2011010559 @default.
- W2079355263 cites W2011377445 @default.
- W2079355263 cites W2011746704 @default.
- W2079355263 cites W2014237668 @default.
- W2079355263 cites W2014528583 @default.
- W2079355263 cites W2016657808 @default.
- W2079355263 cites W2020364703 @default.
- W2079355263 cites W2020948325 @default.
- W2079355263 cites W2021089495 @default.
- W2079355263 cites W2023573350 @default.
- W2079355263 cites W2028560153 @default.
- W2079355263 cites W2030737581 @default.
- W2079355263 cites W2033834161 @default.
- W2079355263 cites W2035185718 @default.
- W2079355263 cites W2035856967 @default.
- W2079355263 cites W2036258772 @default.
- W2079355263 cites W2049317577 @default.
- W2079355263 cites W2057246560 @default.
- W2079355263 cites W2060351304 @default.
- W2079355263 cites W2060774684 @default.
- W2079355263 cites W2068342886 @default.
- W2079355263 cites W2068867459 @default.
- W2079355263 cites W2078573496 @default.
- W2079355263 cites W2079314942 @default.
- W2079355263 cites W2081586027 @default.
- W2079355263 cites W2082214876 @default.
- W2079355263 cites W2082669903 @default.
- W2079355263 cites W2082829736 @default.
- W2079355263 cites W2085600513 @default.
- W2079355263 cites W2089562181 @default.
- W2079355263 cites W2089794760 @default.
- W2079355263 cites W2092067196 @default.
- W2079355263 cites W2102007986 @default.
- W2079355263 cites W2103636227 @default.
- W2079355263 cites W2118310760 @default.
- W2079355263 cites W2122877625 @default.
- W2079355263 cites W2135356424 @default.
- W2079355263 cites W2145889248 @default.
- W2079355263 cites W2165506592 @default.
- W2079355263 cites W2169537677 @default.
- W2079355263 cites W2322095705 @default.
- W2079355263 cites W2338977280 @default.
- W2079355263 cites W2411964537 @default.
- W2079355263 cites W2608539973 @default.
- W2079355263 cites W38523360 @default.
- W2079355263 cites W4238678736 @default.
- W2079355263 cites W4246038430 @default.
- W2079355263 doi "https://doi.org/10.1053/jlts.2001.27476" @default.
- W2079355263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11753902" @default.
- W2079355263 hasPublicationYear "2001" @default.
- W2079355263 type Work @default.
- W2079355263 sameAs 2079355263 @default.
- W2079355263 citedByCount "12" @default.
- W2079355263 countsByYear W20793552632012 @default.
- W2079355263 countsByYear W20793552632023 @default.
- W2079355263 crossrefType "journal-article" @default.
- W2079355263 hasAuthorship W2079355263A5011590009 @default.
- W2079355263 hasBestOaLocation W20793552631 @default.
- W2079355263 hasConcept C104950815 @default.
- W2079355263 hasConcept C126322002 @default.
- W2079355263 hasConcept C134018914 @default.
- W2079355263 hasConcept C134651460 @default.
- W2079355263 hasConcept C181199279 @default.
- W2079355263 hasConcept C2777075537 @default.
- W2079355263 hasConcept C2778163477 @default.
- W2079355263 hasConcept C2779091943 @default.
- W2079355263 hasConcept C2779519902 @default.
- W2079355263 hasConcept C2779609443 @default.
- W2079355263 hasConcept C2908647359 @default.
- W2079355263 hasConcept C2911091166 @default.
- W2079355263 hasConcept C55493867 @default.
- W2079355263 hasConcept C555293320 @default.
- W2079355263 hasConcept C71924100 @default.
- W2079355263 hasConcept C86803240 @default.
- W2079355263 hasConcept C98274493 @default.
- W2079355263 hasConcept C99454951 @default.
- W2079355263 hasConceptScore W2079355263C104950815 @default.