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• W2079355826 abstract "The structural basis of the interaction between the CD4 coreceptor and a class II major histocompatibility complex (MHC) is described. The crystal structure of a complex containing the human CD4 N-terminal two-domain fragment and the murine I-A(k) class II MHC molecule with associated peptide (pMHCII) shows that only the top corner of the CD4 molecule directly contacts pMHCII. The CD4 Phe-43 side chain extends into a hydrophobic concavity formed by MHC residues from both alpha 2 and beta 2 domains. A ternary model of the CD4-pMHCII-T-cell receptor (TCR) reveals that the complex appears V-shaped with the membrane-proximal pMHCII at the apex. This configuration excludes a direct TCR-CD4 interaction and suggests how TCR and CD4 signaling is coordinated around the antigenic pMHCII complex. Human CD4 binds to HIV gp120 in a manner strikingly similar to the way in which CD4 interacts with pMHCII. Additional contacts between gp120 and CD4 give the CD4-gp120 complex a greater affinity. Thus, ligation of the viral envelope glycoprotein to CD4 occludes the pMHCII-binding site on CD4, contributing to immunodeficiency." @default.
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• W2079355826 date "2001-09-04" @default.
• W2079355826 modified "2023-10-18" @default.
• W2079355826 title "Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule" @default.
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• W2079355826 doi "https://doi.org/10.1073/pnas.191124098" @default.
• W2079355826 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/59561" @default.
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