FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079357498> ?p ?o ?g. }

• W2079357498 endingPage "131" @default.
• W2079357498 startingPage "119" @default.
• W2079357498 abstract "The effects of the Cl- channel antagonists, niflumic acid (NFA), dichloro-diphenylamine 2-carboxylic acid (DCDPC) and diisothiocyanato-stilbene-2,2'-disulphonic acid (DIDS) on Ca2+-activated Cl- current (I(Cl(Ca))) evoked by adding fixed intracellular calcium concentrations ([Ca2+]i) to the pipette solution were studied in rabbit pulmonary artery myocytes. With 250 and 500 nM [Ca2+]i bath application of NFA (100 microM) increased inward current at negative potentials, but inhibited outward current at positive potentials. On wash out of NFA, I(Cl(Ca)) was greatly enhanced at all potentials. When external Na+ ions were replaced by N-methyl-D-glucamine (NMDG+) NFA still enhanced I(Cl(Ca)) at negative potentials but the increase of I(Cl(Ca)) on wash out was blocked. When the mean reversal potential (E(r)) of I(Cl(Ca)) was shifted to negative potentials by replacing external Cl- with SCN-, NFA increased inward current but blocked outward current suggesting that the effect of NFA is dependent on current flow. Inclusion of NFA in the pipette solution had no effect on I(Cl(Ca)). Voltage jump experiments indicated that I(Cl(Ca)) displayed characteristic outward current relaxations at +70 mV and inward current relaxations at -80 mV that were abolished by NFA. DCDPC (100 microM) produced similar effects to NFA but 1 mM DIDS produced inhibition of I(Cl(Ca)) at both positive and negative potentials and there was no increase in current on wash out of DIDS. These results suggest that NFA and DCDPC, but not DIDS, simultaneously enhance and block I(Cl(Ca)) by binding to an external site, probably close to the mouth of the chloride channel." @default.
• W2079357498 created "2016-06-24" @default.
• W2079357498 creator A5026338586 @default.
• W2079357498 creator A5066764552 @default.
• W2079357498 creator A5078907845 @default.
• W2079357498 date "2002-02-01" @default.
• W2079357498 modified "2023-10-18" @default.
• W2079357498 title "Dual effect of blocking agents on Ca²⁺‐activated Cl⁻ currents in rabbit pulmonary artery smooth muscle cells" @default.
• W2079357498 cites W1894088205 @default.
• W2079357498 cites W1965665332 @default.
• W2079357498 cites W1976245812 @default.
• W2079357498 cites W1976780677 @default.
• W2079357498 cites W1979132448 @default.
• W2079357498 cites W1979306509 @default.
• W2079357498 cites W1989323461 @default.
• W2079357498 cites W1997004049 @default.
• W2079357498 cites W1997782840 @default.
• W2079357498 cites W2011950318 @default.
• W2079357498 cites W2014856276 @default.
• W2079357498 cites W2021950528 @default.
• W2079357498 cites W2031765503 @default.
• W2079357498 cites W2031897610 @default.
• W2079357498 cites W2047974033 @default.
• W2079357498 cites W2048501360 @default.
• W2079357498 cites W2058392358 @default.
• W2079357498 cites W2070205556 @default.
• W2079357498 cites W2123832242 @default.
• W2079357498 cites W2146556180 @default.
• W2079357498 cites W2171358667 @default.
• W2079357498 cites W2399057662 @default.
• W2079357498 cites W2402144071 @default.
• W2079357498 doi "https://doi.org/10.1113/jphysiol.2001.013270" @default.
• W2079357498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2290117" @default.
• W2079357498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11850506" @default.
• W2079357498 hasPublicationYear "2002" @default.
• W2079357498 type Work @default.
• W2079357498 sameAs 2079357498 @default.
• W2079357498 citedByCount "56" @default.
• W2079357498 countsByYear W20793574982012 @default.
• W2079357498 countsByYear W20793574982013 @default.
• W2079357498 countsByYear W20793574982014 @default.
• W2079357498 countsByYear W20793574982015 @default.
• W2079357498 countsByYear W20793574982016 @default.
• W2079357498 countsByYear W20793574982018 @default.
• W2079357498 countsByYear W20793574982019 @default.
• W2079357498 countsByYear W20793574982022 @default.
• W2079357498 crossrefType "journal-article" @default.
• W2079357498 hasAuthorship W2079357498A5026338586 @default.
• W2079357498 hasAuthorship W2079357498A5066764552 @default.
• W2079357498 hasAuthorship W2079357498A5078907845 @default.
• W2079357498 hasBestOaLocation W20793574982 @default.
• W2079357498 hasConcept C113196181 @default.
• W2079357498 hasConcept C12554922 @default.
• W2079357498 hasConcept C147944092 @default.
• W2079357498 hasConcept C155647269 @default.
• W2079357498 hasConcept C170493617 @default.
• W2079357498 hasConcept C178790620 @default.
• W2079357498 hasConcept C185592680 @default.
• W2079357498 hasConcept C2778071365 @default.
• W2079357498 hasConcept C2779533339 @default.
• W2079357498 hasConcept C2779700409 @default.
• W2079357498 hasConcept C41625074 @default.
• W2079357498 hasConcept C43617362 @default.
• W2079357498 hasConcept C519063684 @default.
• W2079357498 hasConcept C55493867 @default.
• W2079357498 hasConcept C71240020 @default.
• W2079357498 hasConcept C86803240 @default.
• W2079357498 hasConceptScore W2079357498C113196181 @default.
• W2079357498 hasConceptScore W2079357498C12554922 @default.
• W2079357498 hasConceptScore W2079357498C147944092 @default.
• W2079357498 hasConceptScore W2079357498C155647269 @default.
• W2079357498 hasConceptScore W2079357498C170493617 @default.
• W2079357498 hasConceptScore W2079357498C178790620 @default.
• W2079357498 hasConceptScore W2079357498C185592680 @default.
• W2079357498 hasConceptScore W2079357498C2778071365 @default.
• W2079357498 hasConceptScore W2079357498C2779533339 @default.
• W2079357498 hasConceptScore W2079357498C2779700409 @default.
• W2079357498 hasConceptScore W2079357498C41625074 @default.
• W2079357498 hasConceptScore W2079357498C43617362 @default.
• W2079357498 hasConceptScore W2079357498C519063684 @default.
• W2079357498 hasConceptScore W2079357498C55493867 @default.
• W2079357498 hasConceptScore W2079357498C71240020 @default.
• W2079357498 hasConceptScore W2079357498C86803240 @default.
• W2079357498 hasIssue "1" @default.
• W2079357498 hasLocation W20793574981 @default.
• W2079357498 hasLocation W20793574982 @default.
• W2079357498 hasLocation W20793574983 @default.
• W2079357498 hasOpenAccess W2079357498 @default.
• W2079357498 hasPrimaryLocation W20793574981 @default.
• W2079357498 hasRelatedWork W1550371055 @default.
• W2079357498 hasRelatedWork W1995880904 @default.
• W2079357498 hasRelatedWork W1996037418 @default.
• W2079357498 hasRelatedWork W1999581470 @default.
• W2079357498 hasRelatedWork W2014854703 @default.
• W2079357498 hasRelatedWork W2046293336 @default.
• W2079357498 hasRelatedWork W2065933511 @default.
• W2079357498 hasRelatedWork W2079357498 @default.
• W2079357498 hasRelatedWork W2157660476 @default.

• next