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- W2079357599 abstract "The nonpsychoactive plant cannabinoid, (−)-cannabidiol, modulates in vivo responses to Δ 9 -tetrahydrocannabinol. We have found that cannabidiol can also interact with cannabinoid CB 1 receptor agonists in the mouse vas deferens, a tissue in which prejunctional cannabinoid CB 1 receptors mediate inhibition of electrically evoked contractions by suppressing noradrenaline and/or ATP release. Cannabidiol (0.316–10 μM) attenuated the ability of ( R )-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone ( R -(+)-WIN55212) to inhibit contractions in a concentration-related, surmountable manner with a K B value (120.3 nM) well below its reported cannabinoid receptor CB 1 /CB 2 K i values. Cannabidiol (10 μM) also antagonized (−)- cis -3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]- trans -4-(3-hydroxypropyl)cyclohexanol (CP55940; K B =34 nM) and [ d -Ala 2 , NMePhe 4 , Gly-ol]enkephalin (DAMGO; K B =5.6 μM) and attenuated contractile responses to noradrenaline, phenylephrine and methoxamine but not to β, γ-methyleneadenosine 5′-triphosphate. At 3.16–10 μM, it increased the amplitude of evoked contractions, probably by enhancing contractile neurotransmitter release. We conclude that cannabidiol antagonizes R -(+)-WIN55212 and CP55940 by acting at prejunctional sites that are unlikely to be cannabinoid CB 1 or CB 2 receptors." @default.
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- W2079357599 date "2002-12-01" @default.
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- W2079357599 title "(−)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens" @default.
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- W2079357599 doi "https://doi.org/10.1016/s0014-2999(02)02624-9" @default.
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