FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079358450> ?p ?o ?g. }

• W2079358450 endingPage "617" @default.
• W2079358450 startingPage "611" @default.
• W2079358450 abstract "Prevention of intestinal infection by Entamoeba histolytica would block both invasive disease and parasite transmission. The amebic Gal/GalNAc lectin mediates parasite adherence to the colonic surface and fecal anti-lectin IgA is associated with protection from intestinal reinfection in children. We tested if vaccination with the E. histolytica Gal/GalNAc lectin could prevent cecal infection in a C3H mouse model of amebic colitis. Two trials using native lectin purified from the parasite and two trials using a 64 kDa recombinant fragment (LecA) were performed with a combined intranasal and intraperitoneal immunization regimen using cholera toxin and Freund's adjuvants, respectively. Two weeks after immunization mice were challenged intracecally with trophozoites, and 4-12 weeks after challenge mice were sacrificed for histopathologic evaluation of infection. Vaccination prevented intestinal infection with efficacies of 84 and 100% in the two native lectin trials and 91 and 34% in the two LecA trials. Mice with detectable pre-challenge fecal anti-lectin IgA responses were significantly more resistant to infection than mice without fecal anti-lectin IgA responses. These results show for the first time that immunization with the Gal/GalNAc lectin can prevent intestinal amebiasis in mice and suggest a protective role for fecal anti-lectin IgA in vivo." @default.
• W2079358450 created "2016-06-24" @default.
• W2079358450 creator A5007061685 @default.
• W2079358450 creator A5032503392 @default.
• W2079358450 creator A5050404191 @default.
• W2079358450 creator A5056135307 @default.
• W2079358450 creator A5061195866 @default.
• W2079358450 creator A5061972573 @default.
• W2079358450 creator A5075001184 @default.
• W2079358450 date "2004-01-01" @default.
• W2079358450 modified "2023-09-27" @default.
• W2079358450 title "Prevention of intestinal amebiasis by vaccination with the Entamoeba histolytica Gal/GalNac lectin" @default.
• W2079358450 cites W1763341724 @default.
• W2079358450 cites W1985689820 @default.
• W2079358450 cites W1995980810 @default.
• W2079358450 cites W1997067191 @default.
• W2079358450 cites W2006471138 @default.
• W2079358450 cites W2023849726 @default.
• W2079358450 cites W2024099612 @default.
• W2079358450 cites W2040690994 @default.
• W2079358450 cites W2059905961 @default.
• W2079358450 cites W2077752559 @default.
• W2079358450 cites W2091444174 @default.
• W2079358450 cites W2096293859 @default.
• W2079358450 cites W2097185321 @default.
• W2079358450 cites W2102712663 @default.
• W2079358450 cites W2103441801 @default.
• W2079358450 cites W2110073793 @default.
• W2079358450 cites W2113601131 @default.
• W2079358450 cites W2125213202 @default.
• W2079358450 cites W2125525258 @default.
• W2079358450 cites W2136886068 @default.
• W2079358450 cites W2137783202 @default.
• W2079358450 cites W2139020670 @default.
• W2079358450 cites W2140238241 @default.
• W2079358450 cites W2153872813 @default.
• W2079358450 cites W2166373075 @default.
• W2079358450 cites W2418847543 @default.
• W2079358450 cites W4231017639 @default.
• W2079358450 doi "https://doi.org/10.1016/j.vaccine.2003.09.003" @default.
• W2079358450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14741152" @default.
• W2079358450 hasPublicationYear "2004" @default.
• W2079358450 type Work @default.
• W2079358450 sameAs 2079358450 @default.
• W2079358450 citedByCount "92" @default.
• W2079358450 countsByYear W20793584502012 @default.
• W2079358450 countsByYear W20793584502013 @default.
• W2079358450 countsByYear W20793584502014 @default.
• W2079358450 countsByYear W20793584502015 @default.
• W2079358450 countsByYear W20793584502016 @default.
• W2079358450 countsByYear W20793584502017 @default.
• W2079358450 countsByYear W20793584502018 @default.
• W2079358450 countsByYear W20793584502019 @default.
• W2079358450 countsByYear W20793584502020 @default.
• W2079358450 countsByYear W20793584502021 @default.
• W2079358450 countsByYear W20793584502022 @default.
• W2079358450 crossrefType "journal-article" @default.
• W2079358450 hasAuthorship W2079358450A5007061685 @default.
• W2079358450 hasAuthorship W2079358450A5032503392 @default.
• W2079358450 hasAuthorship W2079358450A5050404191 @default.
• W2079358450 hasAuthorship W2079358450A5056135307 @default.
• W2079358450 hasAuthorship W2079358450A5061195866 @default.
• W2079358450 hasAuthorship W2079358450A5061972573 @default.
• W2079358450 hasAuthorship W2079358450A5075001184 @default.
• W2079358450 hasConcept C159047783 @default.
• W2079358450 hasConcept C203014093 @default.
• W2079358450 hasConcept C22070199 @default.
• W2079358450 hasConcept C2776867272 @default.
• W2079358450 hasConcept C2780758401 @default.
• W2079358450 hasConcept C2780801004 @default.
• W2079358450 hasConcept C86803240 @default.
• W2079358450 hasConcept C8891405 @default.
• W2079358450 hasConcept C89423630 @default.
• W2079358450 hasConceptScore W2079358450C159047783 @default.
• W2079358450 hasConceptScore W2079358450C203014093 @default.
• W2079358450 hasConceptScore W2079358450C22070199 @default.
• W2079358450 hasConceptScore W2079358450C2776867272 @default.
• W2079358450 hasConceptScore W2079358450C2780758401 @default.
• W2079358450 hasConceptScore W2079358450C2780801004 @default.
• W2079358450 hasConceptScore W2079358450C86803240 @default.
• W2079358450 hasConceptScore W2079358450C8891405 @default.
• W2079358450 hasConceptScore W2079358450C89423630 @default.
• W2079358450 hasIssue "5-6" @default.
• W2079358450 hasLocation W20793584501 @default.
• W2079358450 hasLocation W20793584502 @default.
• W2079358450 hasOpenAccess W2079358450 @default.
• W2079358450 hasPrimaryLocation W20793584501 @default.
• W2079358450 hasRelatedWork W1487857142 @default.
• W2079358450 hasRelatedWork W1865764402 @default.
• W2079358450 hasRelatedWork W2019797888 @default.
• W2079358450 hasRelatedWork W2072200001 @default.
• W2079358450 hasRelatedWork W2111896892 @default.
• W2079358450 hasRelatedWork W2127593648 @default.
• W2079358450 hasRelatedWork W2435690523 @default.
• W2079358450 hasRelatedWork W2962682510 @default.
• W2079358450 hasRelatedWork W2974282048 @default.
• W2079358450 hasRelatedWork W979319891 @default.
• W2079358450 hasVolume "22" @default.

• next