Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079360025> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2079360025 abstract "Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, ILThe REarranged in Transfection (RET) tyrosine kinase is important during development of neural crest derived tissues such as the enteric and sympathetic nervous systems, but is also activated in multiple human tumour types. Activating mutations of RET play an important role in thyroid cancers including both papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC). More broadly, recent studies have also shown that RET may be active in other tumour types such as pancreatic and breast cancers, and that the overexpression and activation of RET may be linked to more aggressive disease. In order to explore this link, we have investigated the expression of RET in a large cohort of over 400 thyroid tumour samples of multiple histologies, ranging from benign lesions through to aggressive, metastatic disease by immunhistochemistry using a thyroid tissue microarray. Our data suggest that RET expression may correlate with more aggressive phenotype across a broader spectrum of tumours than previously predicted. We are currently investigating this association further; first by examining the expression of two major RET protein isoforms, RET9 and RET51, in this panel of tumours, and second, by investigating the coexpression of RET with another group of proteins associated with tumour progression, the integrin family. In preliminary studies, we have evaluated RET coexpression with two integrin subunits, ITGB1 and ITGB3. Our data suggest correlation between tumour aggressiveness and coexpression of RET with these integrin subunits. Together, our data provides insight on the role of RET in increasing aggressiveness over a range of tumours.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 943. doi:1538-7445.AM2012-943" @default.
- W2079360025 created "2016-06-24" @default.
- W2079360025 creator A5005590576 @default.
- W2079360025 creator A5006788519 @default.
- W2079360025 creator A5010860180 @default.
- W2079360025 creator A5027508426 @default.
- W2079360025 creator A5029332910 @default.
- W2079360025 creator A5054009874 @default.
- W2079360025 creator A5065285863 @default.
- W2079360025 creator A5080989882 @default.
- W2079360025 date "2012-04-15" @default.
- W2079360025 modified "2023-09-27" @default.
- W2079360025 title "Abstract 943: Characterization of RET and integrin signaling in thyroid tumors" @default.
- W2079360025 doi "https://doi.org/10.1158/1538-7445.am2012-943" @default.
- W2079360025 hasPublicationYear "2012" @default.
- W2079360025 type Work @default.
- W2079360025 sameAs 2079360025 @default.
- W2079360025 citedByCount "0" @default.
- W2079360025 crossrefType "proceedings-article" @default.
- W2079360025 hasAuthorship W2079360025A5005590576 @default.
- W2079360025 hasAuthorship W2079360025A5006788519 @default.
- W2079360025 hasAuthorship W2079360025A5010860180 @default.
- W2079360025 hasAuthorship W2079360025A5027508426 @default.
- W2079360025 hasAuthorship W2079360025A5029332910 @default.
- W2079360025 hasAuthorship W2079360025A5054009874 @default.
- W2079360025 hasAuthorship W2079360025A5065285863 @default.
- W2079360025 hasAuthorship W2079360025A5080989882 @default.
- W2079360025 hasConcept C101544691 @default.
- W2079360025 hasConcept C104317684 @default.
- W2079360025 hasConcept C126322002 @default.
- W2079360025 hasConcept C126749454 @default.
- W2079360025 hasConcept C127716648 @default.
- W2079360025 hasConcept C142724271 @default.
- W2079360025 hasConcept C160539049 @default.
- W2079360025 hasConcept C170493617 @default.
- W2079360025 hasConcept C185856081 @default.
- W2079360025 hasConcept C193270364 @default.
- W2079360025 hasConcept C204232928 @default.
- W2079360025 hasConcept C2779761222 @default.
- W2079360025 hasConcept C2908751931 @default.
- W2079360025 hasConcept C2993294228 @default.
- W2079360025 hasConcept C42362537 @default.
- W2079360025 hasConcept C502942594 @default.
- W2079360025 hasConcept C526584372 @default.
- W2079360025 hasConcept C54355233 @default.
- W2079360025 hasConcept C71924100 @default.
- W2079360025 hasConcept C86803240 @default.
- W2079360025 hasConceptScore W2079360025C101544691 @default.
- W2079360025 hasConceptScore W2079360025C104317684 @default.
- W2079360025 hasConceptScore W2079360025C126322002 @default.
- W2079360025 hasConceptScore W2079360025C126749454 @default.
- W2079360025 hasConceptScore W2079360025C127716648 @default.
- W2079360025 hasConceptScore W2079360025C142724271 @default.
- W2079360025 hasConceptScore W2079360025C160539049 @default.
- W2079360025 hasConceptScore W2079360025C170493617 @default.
- W2079360025 hasConceptScore W2079360025C185856081 @default.
- W2079360025 hasConceptScore W2079360025C193270364 @default.
- W2079360025 hasConceptScore W2079360025C204232928 @default.
- W2079360025 hasConceptScore W2079360025C2779761222 @default.
- W2079360025 hasConceptScore W2079360025C2908751931 @default.
- W2079360025 hasConceptScore W2079360025C2993294228 @default.
- W2079360025 hasConceptScore W2079360025C42362537 @default.
- W2079360025 hasConceptScore W2079360025C502942594 @default.
- W2079360025 hasConceptScore W2079360025C526584372 @default.
- W2079360025 hasConceptScore W2079360025C54355233 @default.
- W2079360025 hasConceptScore W2079360025C71924100 @default.
- W2079360025 hasConceptScore W2079360025C86803240 @default.
- W2079360025 hasLocation W20793600251 @default.
- W2079360025 hasOpenAccess W2079360025 @default.
- W2079360025 hasPrimaryLocation W20793600251 @default.
- W2079360025 hasRelatedWork W1972546974 @default.
- W2079360025 hasRelatedWork W1979949328 @default.
- W2079360025 hasRelatedWork W1987425992 @default.
- W2079360025 hasRelatedWork W2034879994 @default.
- W2079360025 hasRelatedWork W2050238137 @default.
- W2079360025 hasRelatedWork W2063858714 @default.
- W2079360025 hasRelatedWork W2088699600 @default.
- W2079360025 hasRelatedWork W2089479851 @default.
- W2079360025 hasRelatedWork W2092966438 @default.
- W2079360025 hasRelatedWork W2129846590 @default.
- W2079360025 hasRelatedWork W2134982299 @default.
- W2079360025 hasRelatedWork W2159673048 @default.
- W2079360025 hasRelatedWork W2163840257 @default.
- W2079360025 hasRelatedWork W2259987557 @default.
- W2079360025 hasRelatedWork W2354977616 @default.
- W2079360025 hasRelatedWork W2403869272 @default.
- W2079360025 hasRelatedWork W2509896132 @default.
- W2079360025 hasRelatedWork W2946942811 @default.
- W2079360025 hasRelatedWork W2986237592 @default.
- W2079360025 hasRelatedWork W59071721 @default.
- W2079360025 isParatext "false" @default.
- W2079360025 isRetracted "false" @default.
- W2079360025 magId "2079360025" @default.
- W2079360025 workType "article" @default.