FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079362203> ?p ?o ?g. }

• W2079362203 endingPage "96" @default.
• W2079362203 startingPage "87" @default.
• W2079362203 abstract "BM-531 (N-tert-butyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative, is a novel noncarboxylic thromboxane receptor antagonist and thromboxane synthase inhibitor. Indeed, its affinity for human washed platelet TXA2 receptors labeled with [3H]SQ-29548 (IC50 = 0.0078 microM) is higher than sulotroban (IC50 = 0.93 microM) and SQ-29548 (IC50 = 0.021 microM). Moreover, BM-531 is characterized by a potent antiaggregatory property. Indeed, on one hand, in human citrated platelet-rich plasma BM-531 prevents platelet aggregation induced by arachidonic acid (600 microM) (ED100 = 0.125 microM), U-46619, a stable TXA2 agonist (1 microM) (ED50 = 0.482 microM) or collagen (1 microgram/mL) (percentage of inhibition: 42.9% at 10 microM) and inhibits the second wave of ADP (2 microM)-induced aggregation. On the other hand, when BM-531 is incubated in whole blood from healthy donors, the closure time measured by the recently developed platelet function analyser (PFA-100) is significantly prolonged. In addition, at the concentrations of 10 and 1 microM, BM-531 totally prevents the production of TXB2 by human platelets activated by arachidonic acid. Finally, at 10 microM, BM-531 significantly prevents rat fundus contractions induced by U-46619 but not by prostacyclin. These results suggest that BM-531, which is devoid of the diuretic property of torasemide, can be regarded as a promising antiplatelet agent." @default.
• W2079362203 created "2016-06-24" @default.
• W2079362203 creator A5001454349 @default.
• W2079362203 creator A5007385525 @default.
• W2079362203 creator A5010046842 @default.
• W2079362203 creator A5020685154 @default.
• W2079362203 creator A5029574559 @default.
• W2079362203 creator A5036233186 @default.
• W2079362203 creator A5041424887 @default.
• W2079362203 creator A5075865638 @default.
• W2079362203 creator A5081430054 @default.
• W2079362203 creator A5087042354 @default.
• W2079362203 date "2001-06-01" @default.
• W2079362203 modified "2023-10-09" @default.
• W2079362203 title "Pharmacology of the Thromboxane Receptor Antagonist and Thromboxane Synthase Inhibitor BM-531" @default.
• W2079362203 cites W1239246082 @default.
• W2079362203 cites W1966682207 @default.
• W2079362203 cites W1977478181 @default.
• W2079362203 cites W1980727193 @default.
• W2079362203 cites W1981159906 @default.
• W2079362203 cites W1982612302 @default.
• W2079362203 cites W1984265477 @default.
• W2079362203 cites W2004067421 @default.
• W2079362203 cites W2008839219 @default.
• W2079362203 cites W2010694924 @default.
• W2079362203 cites W2011166322 @default.
• W2079362203 cites W2015211989 @default.
• W2079362203 cites W2019171004 @default.
• W2079362203 cites W2020292796 @default.
• W2079362203 cites W2026643960 @default.
• W2079362203 cites W2030087792 @default.
• W2079362203 cites W2041338618 @default.
• W2079362203 cites W2054262691 @default.
• W2079362203 cites W2055693070 @default.
• W2079362203 cites W2081402100 @default.
• W2079362203 cites W2088074734 @default.
• W2079362203 cites W2093106202 @default.
• W2079362203 cites W2117682533 @default.
• W2079362203 cites W2137549234 @default.
• W2079362203 cites W2319834083 @default.
• W2079362203 cites W2472542224 @default.
• W2079362203 cites W2513442199 @default.
• W2079362203 cites W4239471829 @default.
• W2079362203 doi "https://doi.org/10.1111/j.1527-3466.2001.tb00057.x" @default.
• W2079362203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11484064" @default.
• W2079362203 hasPublicationYear "2001" @default.
• W2079362203 type Work @default.
• W2079362203 sameAs 2079362203 @default.
• W2079362203 citedByCount "25" @default.
• W2079362203 countsByYear W20793622032014 @default.
• W2079362203 countsByYear W20793622032018 @default.
• W2079362203 countsByYear W20793622032019 @default.
• W2079362203 crossrefType "journal-article" @default.
• W2079362203 hasAuthorship W2079362203A5001454349 @default.
• W2079362203 hasAuthorship W2079362203A5007385525 @default.
• W2079362203 hasAuthorship W2079362203A5010046842 @default.
• W2079362203 hasAuthorship W2079362203A5020685154 @default.
• W2079362203 hasAuthorship W2079362203A5029574559 @default.
• W2079362203 hasAuthorship W2079362203A5036233186 @default.
• W2079362203 hasAuthorship W2079362203A5041424887 @default.
• W2079362203 hasAuthorship W2079362203A5075865638 @default.
• W2079362203 hasAuthorship W2079362203A5081430054 @default.
• W2079362203 hasAuthorship W2079362203A5087042354 @default.
• W2079362203 hasBestOaLocation W20793622031 @default.
• W2079362203 hasConcept C126322002 @default.
• W2079362203 hasConcept C134018914 @default.
• W2079362203 hasConcept C170493617 @default.
• W2079362203 hasConcept C173202427 @default.
• W2079362203 hasConcept C181199279 @default.
• W2079362203 hasConcept C185592680 @default.
• W2079362203 hasConcept C2776785769 @default.
• W2079362203 hasConcept C2778078955 @default.
• W2079362203 hasConcept C2778938600 @default.
• W2079362203 hasConcept C2781024287 @default.
• W2079362203 hasConcept C55493867 @default.
• W2079362203 hasConcept C71924100 @default.
• W2079362203 hasConcept C89560881 @default.
• W2079362203 hasConcept C98274493 @default.
• W2079362203 hasConceptScore W2079362203C126322002 @default.
• W2079362203 hasConceptScore W2079362203C134018914 @default.
• W2079362203 hasConceptScore W2079362203C170493617 @default.
• W2079362203 hasConceptScore W2079362203C173202427 @default.
• W2079362203 hasConceptScore W2079362203C181199279 @default.
• W2079362203 hasConceptScore W2079362203C185592680 @default.
• W2079362203 hasConceptScore W2079362203C2776785769 @default.
• W2079362203 hasConceptScore W2079362203C2778078955 @default.
• W2079362203 hasConceptScore W2079362203C2778938600 @default.
• W2079362203 hasConceptScore W2079362203C2781024287 @default.
• W2079362203 hasConceptScore W2079362203C55493867 @default.
• W2079362203 hasConceptScore W2079362203C71924100 @default.
• W2079362203 hasConceptScore W2079362203C89560881 @default.
• W2079362203 hasConceptScore W2079362203C98274493 @default.
• W2079362203 hasIssue "2" @default.
• W2079362203 hasLocation W20793622031 @default.
• W2079362203 hasLocation W20793622032 @default.
• W2079362203 hasOpenAccess W2079362203 @default.
• W2079362203 hasPrimaryLocation W20793622031 @default.
• W2079362203 hasRelatedWork W1541108101 @default.

• next