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• W2079363783 abstract "We investigated the effects of human rIL-4 on in vitro hematopoiesis. A profound inhibition of macrophage colony formation by IL-4 was observed, whereas colony growth of other lineages was not affected. Inhibition of macrophage colony growth was not restricted to GM-CSF-induced colony growth but was also present in cultures stimulated with M-CSF. This inhibition was not only observed in cultures of light density bone marrow cells, but also in cultures of monocyte- and T lymphocyte-depleted bone marrow cells. Since a similar inhibition was observed in cultures of CD34+HLA-DR+-enriched bone marrow cells, a direct action of IL-4 on monocyte-committed progenitor cells is suggested." @default.
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• W2079363783 date "1989-08-01" @default.
• W2079363783 modified "2023-09-25" @default.
• W2079363783 title "Inhibition of human macrophage colony formation by interleukin 4." @default.
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• W2079363783 doi "https://doi.org/10.1084/jem.170.2.577" @default.
• W2079363783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2189394" @default.
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