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- W2079366245 abstract "Platelet-activating factor(1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine or AGEPC) is a small, extremely potent phospholipid mediator. CV-3988, a unique structural analogue of AGEPC, has recently been introduced as a selective antagonist of AGEPC-induced platelet activation and systemic hypotension. At concentrations greater than 5 × 10−5 M, CV-3988 itself induced aggregation and secretion responses in washed rabbit platelets. CV-3988 inhibited AGEPC-induced platelet activation at concentrations as low as 10−8 M, but also blocked platelet activation induced by collagen and calcium ionophore A23187 at concentrations between 10−6M and 10−5M. The mechanism of inhibition, however, did not depend on increased levels of intracellular 31,51-cyclic adenosine monophosphate (CAMP). In fact, CV-3988, like AGEPC itself, appeared to lower cAMP levels in washed rabbit platelets." @default.
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- W2079366245 date "1986-01-01" @default.
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- W2079366245 title "Effects of cv-3988, an antagonist of platelet-activating factor (paf), on washed rabbit platelets" @default.
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- W2079366245 doi "https://doi.org/10.1016/0049-3848(86)90230-6" @default.
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