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- W2079367439 abstract "A novel direct high-performance liquid chromatographic (HPLC) assay for the simultaneous determination of three salicylate glucuronide conjugates and other salicylate metabolites in human urine has been developed. Salicylate glucuronide conjugates were purified by HPLC from the urine of a volunteer after oral administration of aspirin and identified by selective hydrolysis with β-glucuronidase and with sodium hydroxide. This method gave high reproducibility with coefficients of variation less than 10%. The total urinary recovery of salicylic acid after a single 1.2-g dose of soluble aspirin was greater than 90%. This assay has been successfully used to re-evaluate the capacity-limited pharmacokinetics of salicylic acid in humans." @default.
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- W2079367439 date "1991-04-01" @default.
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- W2079367439 title "Novel direct high-performance liquid chromatographic method for determination of salicylate glucuronide conjugates in human urine" @default.
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- W2079367439 doi "https://doi.org/10.1016/0378-4347(91)80392-p" @default.
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