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• W2079369518 endingPage "e25047" @default.
• W2079369518 startingPage "e25047" @default.
• W2079369518 abstract "The ability to modulate gene expression in response to sensory experience is critical to the normal development and function of the nervous system. Calcium is a key activator of the signal transduction cascades that mediate the process of translating a cellular stimulus into transcriptional changes. With the recent discovery that the mammalian Cav1.2 calcium channel can be cleaved, enter the nucleus and act as a transcription factor to control neuronal gene expression, a more direct role for the calcium channels themselves in regulating transcription has begun to be appreciated. Here we report the identification of a nuclear localization sequence (NLS) in the C. elegans transient receptor potential vanilloid (TRPV) cation channel OCR-2. TRPV channels have previously been implicated in transcriptional regulation of neuronal genes in the nematode, although the precise mechanism remains unclear. We show that the NLS in OCR-2 is functional, being able to direct nuclear accumulation of a synthetic cargo protein as well as the carboxy-terminal cytosolic tail of OCR-2 where it is endogenously found. Furthermore, we discovered that a carboxy-terminal portion of the full-length channel can localize to the nucleus of neuronal cells. These results suggest that the OCR-2 TRPV cation channel may have a direct nuclear function in neuronal cells that was not previously appreciated." @default.
• W2079369518 created "2016-06-24" @default.
• W2079369518 creator A5007172667 @default.
• W2079369518 creator A5049845282 @default.
• W2079369518 date "2011-09-21" @default.
• W2079369518 modified "2023-09-25" @default.
• W2079369518 title "A Functional Nuclear Localization Sequence in the C. elegans TRPV Channel OCR-2" @default.
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• W2079369518 doi "https://doi.org/10.1371/journal.pone.0025047" @default.
• W2079369518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3177883" @default.
• W2079369518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21957475" @default.
• W2079369518 hasPublicationYear "2011" @default.
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