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- W2079372223 abstract "Tryptophan hydroxylase [EC 1.14.16.4; L-tryptophan, tetrahydropteridine: oxygen oxidoreductase (5-hydroxylating)] in rat brainstem extracts is activated 2 to 2.5-fold by ATP and Mg++ in the presence of subsaturating concentrations of the cofactor 6-methyltetrahydropterin (6MPH4). The activation of tryptophan hydroxylase under these conditions results from a reduction in the apparent Km for 6MPH4 from 0.21 mM to 0.09 mM. The activation requires Mg++ and ATP but is not dependent on either cAMP or cGMP. The effect of ATP and Mg++ on enzyme activity was enhanced by μM concentrations of Ca++ and totally blocked by EGTA. These data suggest that tryptophan hydroxylase can be activated by a cyclic nucleotide independent protein kinase which requires low calcium concentrations for the expression of its activity." @default.
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- W2079372223 date "1978-05-01" @default.
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- W2079372223 title "Calcium-dependent activation of tryptophan hydroxylase by ATP and magnesium" @default.
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- W2079372223 doi "https://doi.org/10.1016/0006-291x(78)90940-3" @default.
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