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- W2079372652 endingPage "e1001777" @default.
- W2079372652 startingPage "e1001777" @default.
- W2079372652 abstract "Vesicular trafficking plays a key role in tuning the activity of Notch signaling. Here, we describe a novel and conserved Rab geranylgeranyltransferase (RabGGT)-α-like subunit that is required for Notch signaling-mediated lateral inhibition and cell fate determination of external sensory organs. This protein is encoded by tempura, and its loss affects the secretion of Scabrous and Delta, two proteins required for proper Notch signaling. We show that Tempura forms a heretofore uncharacterized RabGGT complex that geranylgeranylates Rab1 and Rab11. This geranylgeranylation is required for their proper subcellular localization. A partial dysfunction of Rab1 affects Scabrous and Delta in the secretory pathway. In addition, a partial loss Rab11 affects trafficking of Delta. In summary, Tempura functions as a new geranylgeranyltransferase that regulates the subcellular localization of Rab1 and Rab11, which in turn regulate trafficking of Scabrous and Delta, thereby affecting Notch signaling." @default.
- W2079372652 created "2016-06-24" @default.
- W2079372652 creator A5014129907 @default.
- W2079372652 creator A5026995692 @default.
- W2079372652 creator A5029962410 @default.
- W2079372652 creator A5038039826 @default.
- W2079372652 creator A5055204349 @default.
- W2079372652 creator A5057005768 @default.
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- W2079372652 creator A5063606479 @default.
- W2079372652 creator A5072442988 @default.
- W2079372652 creator A5074134868 @default.
- W2079372652 creator A5076405616 @default.
- W2079372652 creator A5086709976 @default.
- W2079372652 creator A5091154260 @default.
- W2079372652 date "2014-01-28" @default.
- W2079372652 modified "2023-09-26" @default.
- W2079372652 title "Drosophila Tempura, a Novel Protein Prenyltransferase α Subunit, Regulates Notch Signaling Via Rab1 and Rab11" @default.
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