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• W2079374623 abstract "The effect of various nucleotide-enhancing agents on renal function and intracellular nucleotide levels was evaluated in a canine autotransplant model. Thirty-five dogs (18–28 kg) underwent left nephrectomy and 30 min of warm ischemia followed by Collins C-4 flush and 24 hr of cold-storage preservation. Heterotopic autotransplantation and immediate contralateral nephrectomy was then performed. Seven equal groups were evaluated: group A—controls, group B—adenosine pretreatment (1.0 g), group C—dipyridamole pretreatment (10 mg), group D—adenosine (1.0 g), and dipyridamole (10 mg) pretreatment, group E—adenosine (200 mg) and EHNA (2.5 mg/kg) pretreatment, group F—adenosine (200 mg) and EHNA (2.5 mg/kg) in the Collins C-4 flush, and group G—adenosine (200 mg) and EHNA (2.5 mg/kg) at the time of autotransplantation. All kidneys underwent cortical biopsies at the end of preservation and 1 hr after restoration of blood flow for determinations of AMP, ADP, and ATP. In the pretreatment groups (groups B through E) there was 60% graft survival whereas the controls (group A) and the groups treated after ischemia (groups F and G) had 0, 0, and 20% graft survival, respectively. In groups B and E, ATP levels were greater than controls after preservation and 1 hr after restoration of blood flow. Group C AMP and ADP levels and group D energy charge were greater than controls in the post-transplantation biopsies. Administration of adenosine and EHNA after ischemia was not associated with increased intracellular nucleotide levels. One hour post-transplantation biopsies demonstrated greater ability to regenerate cortical nucleotides in the surviving animals but no absolute value could be identified as a predictor of viability. In conclusion, pretreatment with adenosine, dipyridamole, and EHNA alone and in combination is beneficial in ischemically injured kidneys undergoing cold-storage preservation." @default.
• W2079374623 created "2016-06-24" @default.
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• W2079374623 date "1985-01-01" @default.
• W2079374623 modified "2023-10-14" @default.
• W2079374623 title "An experimental evaluation of nucleotide enhancement techniques for kidney transplantation" @default.
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• W2079374623 doi "https://doi.org/10.1016/0022-4804(85)90007-1" @default.
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