FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079378239> ?p ?o ?g. }

• W2079378239 endingPage "219" @default.
• W2079378239 startingPage "211" @default.
• W2079378239 abstract "Aberrant DNA methylation has been shown to play important roles during multistage carcinogenesis in various human organs. The aim of this study was to evaluate the significance of DNA methyltransferase 1 (DNMT1) protein expression during cervical carcinogenesis. We carried out an immunohistochemical examination for DNMT1 in 34 samples of histologically normal squamous epithelium, 36 samples of low-grade cervical intraepithelial neoplasia (CIN), 61 samples of higher-grade CIN and 30 samples of squamous cell carcinoma of the uterine cervix. The DNMT1 protein expression score, reflecting the intensity and incidence of DNMT1 nuclear immunoreactivity, was increased even in low-grade CIN (P<0.0001) in comparison with histologically normal squamous epithelium and was further increased in higher-grade CIN (P<0.0001 compared to low-grade CIN). The DNMT1 protein expression score remained at a plateau in microinvasive carcinoma (Stage IA, P=0.0690 compared to higher-grade CIN) and then decreased with cancer invasion (Stage IB or more, P=0.0176 compared to Stage IA), whereas the proliferating cell nuclear antigen (PCNA) labeling index did not decrease with cancer invasion (P=0.8259 between Stage IA and Stage IB or more). Thus, the DNMT1 protein expression score and the PCNA labeling index were not mutually correlated in squamous cell carcinoma of the uterine cervix (P=0.2304). These data suggest that progressively increasing expression of DNMT1 protein is not entirely a secondary result of increased cell proliferative activity, but is associated with an early step of multistage cervical carcinogenesis." @default.
• W2079378239 created "2016-06-24" @default.
• W2079378239 creator A5001841943 @default.
• W2079378239 creator A5012979592 @default.
• W2079378239 creator A5064680548 @default.
• W2079378239 creator A5074419698 @default.
• W2079378239 creator A5085291337 @default.
• W2079378239 creator A5085871218 @default.
• W2079378239 date "2007-06-01" @default.
• W2079378239 modified "2023-09-27" @default.
• W2079378239 title "Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion" @default.
• W2079378239 cites W1490231232 @default.
• W2079378239 cites W1504303645 @default.
• W2079378239 cites W1528035347 @default.
• W2079378239 cites W1533942477 @default.
• W2079378239 cites W1572264474 @default.
• W2079378239 cites W1579447084 @default.
• W2079378239 cites W1963567995 @default.
• W2079378239 cites W1965800143 @default.
• W2079378239 cites W1969600675 @default.
• W2079378239 cites W1969938956 @default.
• W2079378239 cites W1972049135 @default.
• W2079378239 cites W1972934671 @default.
• W2079378239 cites W1973318715 @default.
• W2079378239 cites W1981554930 @default.
• W2079378239 cites W1982191424 @default.
• W2079378239 cites W1982824410 @default.
• W2079378239 cites W1994193985 @default.
• W2079378239 cites W2002984897 @default.
• W2079378239 cites W2004172747 @default.
• W2079378239 cites W2009178773 @default.
• W2079378239 cites W2015510960 @default.
• W2079378239 cites W2021109810 @default.
• W2079378239 cites W2028563156 @default.
• W2079378239 cites W2029868343 @default.
• W2079378239 cites W2046974465 @default.
• W2079378239 cites W2054443614 @default.
• W2079378239 cites W2055171335 @default.
• W2079378239 cites W2059587308 @default.
• W2079378239 cites W2059598057 @default.
• W2079378239 cites W2075712243 @default.
• W2079378239 cites W2077317303 @default.
• W2079378239 cites W2085023377 @default.
• W2079378239 cites W2093188241 @default.
• W2079378239 cites W2122116522 @default.
• W2079378239 cites W2128380479 @default.
• W2079378239 cites W2133388337 @default.
• W2079378239 cites W2144979911 @default.
• W2079378239 cites W2164456329 @default.
• W2079378239 cites W2167533065 @default.
• W2079378239 doi "https://doi.org/10.1016/j.canlet.2006.11.023" @default.
• W2079378239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17196739" @default.
• W2079378239 hasPublicationYear "2007" @default.
• W2079378239 type Work @default.
• W2079378239 sameAs 2079378239 @default.
• W2079378239 citedByCount "47" @default.
• W2079378239 countsByYear W20793782392012 @default.
• W2079378239 countsByYear W20793782392013 @default.
• W2079378239 countsByYear W20793782392014 @default.
• W2079378239 countsByYear W20793782392015 @default.
• W2079378239 countsByYear W20793782392016 @default.
• W2079378239 countsByYear W20793782392017 @default.
• W2079378239 countsByYear W20793782392018 @default.
• W2079378239 countsByYear W20793782392019 @default.
• W2079378239 countsByYear W20793782392020 @default.
• W2079378239 countsByYear W20793782392021 @default.
• W2079378239 countsByYear W20793782392022 @default.
• W2079378239 countsByYear W20793782392023 @default.
• W2079378239 crossrefType "journal-article" @default.
• W2079378239 hasAuthorship W2079378239A5001841943 @default.
• W2079378239 hasAuthorship W2079378239A5012979592 @default.
• W2079378239 hasAuthorship W2079378239A5064680548 @default.
• W2079378239 hasAuthorship W2079378239A5074419698 @default.
• W2079378239 hasAuthorship W2079378239A5085291337 @default.
• W2079378239 hasAuthorship W2079378239A5085871218 @default.
• W2079378239 hasConcept C121608353 @default.
• W2079378239 hasConcept C142724271 @default.
• W2079378239 hasConcept C175211621 @default.
• W2079378239 hasConcept C204232928 @default.
• W2079378239 hasConcept C2775924586 @default.
• W2079378239 hasConcept C2777343196 @default.
• W2079378239 hasConcept C2777751288 @default.
• W2079378239 hasConcept C2778220009 @default.
• W2079378239 hasConcept C33288867 @default.
• W2079378239 hasConcept C34688535 @default.
• W2079378239 hasConcept C529295009 @default.
• W2079378239 hasConcept C54355233 @default.
• W2079378239 hasConcept C552990157 @default.
• W2079378239 hasConcept C555283112 @default.
• W2079378239 hasConcept C71924100 @default.
• W2079378239 hasConcept C86803240 @default.
• W2079378239 hasConcept C91965660 @default.
• W2079378239 hasConceptScore W2079378239C121608353 @default.
• W2079378239 hasConceptScore W2079378239C142724271 @default.
• W2079378239 hasConceptScore W2079378239C175211621 @default.
• W2079378239 hasConceptScore W2079378239C204232928 @default.
• W2079378239 hasConceptScore W2079378239C2775924586 @default.
• W2079378239 hasConceptScore W2079378239C2777343196 @default.

• next