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- W2079380206 abstract "The treatment of disseminated intra-abdominal malignancy with a surgical procedure accompanied by intraperitoneal chemotherapy has at least a 25-year history. 1 Speyer J.L. Collins J.M. Dedrick R.L. Brennan M.F. Buckpitt A.R. Londer H. et al. Phase I in pharmacological studies of 5-fluorouracil administered intraperitoneally. Cancer Res. 1980; 40: 567-572 PubMed Google Scholar There have been a number of vigorous proponents of this technique. 2 Sugarbaker P.H. Cytoreductive surgery and peri-operative intraperitoneal chemotherapy as a curative approach to pseudomyxoma peritonei syndrome. Eur J Surg Oncol. 2001; 27: 239-243 Abstract Full Text PDF PubMed Scopus (178) Google Scholar Even in the management of ovarian cancer, for which effective drugs exist, randomized trials have been equivocal for overall survival and have shown only some benefit for progression-free survival. 3 Markman M. Intraperitoneal chemotherapy in the management of ovarian cancer. JNCCN. 2004; 2: 549-554 PubMed Google Scholar , 4 Ozols R.F. Intraperitoneal chemotherapy: an investigational treatment in ovarian cancer. JNCCN. 2004; 2: 555-560 PubMed Google Scholar For other solid tumors, the approach has not been universally supported, and many have suggested that as in most malignant systems, it is biology rather than the technological approach to tumor eradication that determines outcome. Dr Elias and colleagues 5 Elias D. Sideris L. Liberale G. Ducreux M. Malka D. Lasser P. et al. Surgical treatment of peritoneal carcinomatosis from well differentiated digestive endocrine carcinomas. Surgery. 2005; 137: 411-416 Abstract Full Text Full Text PDF PubMed Scopus (54) Google Scholar are enthusiastic proponents of the approach and provide evidence to support its application to differentiated endocrine carcinoma." @default.
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- W2079380206 date "2005-04-01" @default.
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- W2079380206 title "Invited commentary: Surgery and chemotherapy for peritoneal carcinomatosis—More about selection and biology than treatment?" @default.
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- W2079380206 doi "https://doi.org/10.1016/j.surg.2004.12.013" @default.
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