FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079384071> ?p ?o ?g. }

• W2079384071 endingPage "147" @default.
• W2079384071 startingPage "139" @default.
• W2079384071 abstract "Interleukin 9 (IL-9) is a T-cell derived factor preferentially expressed by CD4+ Th2 cells and it has been characterized both in human and murine systems. It is a pleiotropic cytokine with multiple functions on cells of the lymphoid, myeloid and mast cell lineages, as well as on lung epithelial cells. Other activities described for IL-9 support its contribution to asthma and its important role in helminthic infections, where a Th2 response can be protective and IL-9 enhances resistance or is responsible for elimination of the nematode. Nevertheless, until recently there were no studies on its role in bacterial infections in man. We have demonstrated that cytokines can modulate the specific cytotoxicity generation in peripheral blood mononuclear cells from leprosy patients and normal controls. In the present report we studied the effect of IL-9 in this experimental model. Our results indicate that IL-9 can counteract the negative effect mediated by IL-4 on the generation of M. leprae-induced cytotoxic T lymphocytes. Moreover, it can increase this lytic activity in controls and enhance the stimulatory effect of IL-2 or IL-6 in cells from leprosy patients and controls. IL-9 is also able to revert the inhibitory effect of IL-10 and IL-13 on the M. leprae-induced cytotoxic activity. Although the exact mechanism of action of IL-9 remains to be determined, interferon gamma seems to be required for the effect of IL-9 in this experimental model. These data suggest that IL-9 may have an atypical Th2 behaviour and play a role in the modulation of the immune response to mycobacterial infections." @default.
• W2079384071 created "2016-06-24" @default.
• W2079384071 creator A5007007507 @default.
• W2079384071 creator A5019457819 @default.
• W2079384071 creator A5020830882 @default.
• W2079384071 creator A5021028530 @default.
• W2079384071 creator A5021286534 @default.
• W2079384071 creator A5039171975 @default.
• W2079384071 creator A5057845652 @default.
• W2079384071 creator A5059160872 @default.
• W2079384071 creator A5080770856 @default.
• W2079384071 date "2006-11-14" @default.
• W2079384071 modified "2023-10-03" @default.
• W2079384071 title "IL-9 promotes anti-<i>Mycobacterium leprae</i> cytotoxicity: involvement of IFNγ" @default.
• W2079384071 cites W1538658476 @default.
• W2079384071 cites W1662284013 @default.
• W2079384071 cites W1667482292 @default.
• W2079384071 cites W1834954945 @default.
• W2079384071 cites W1918361100 @default.
• W2079384071 cites W1920701053 @default.
• W2079384071 cites W1950403171 @default.
• W2079384071 cites W1965129479 @default.
• W2079384071 cites W1967915220 @default.
• W2079384071 cites W1982766629 @default.
• W2079384071 cites W2002303891 @default.
• W2079384071 cites W2009641021 @default.
• W2079384071 cites W2020089973 @default.
• W2079384071 cites W2022057794 @default.
• W2079384071 cites W2022201886 @default.
• W2079384071 cites W2035094072 @default.
• W2079384071 cites W2037907738 @default.
• W2079384071 cites W2049719443 @default.
• W2079384071 cites W2055105806 @default.
• W2079384071 cites W2061467287 @default.
• W2079384071 cites W2075176417 @default.
• W2079384071 cites W2075773580 @default.
• W2079384071 cites W2102621382 @default.
• W2079384071 cites W2105578031 @default.
• W2079384071 cites W2133907862 @default.
• W2079384071 cites W2138386305 @default.
• W2079384071 cites W2142479197 @default.
• W2079384071 cites W2154096824 @default.
• W2079384071 cites W2158356076 @default.
• W2079384071 cites W87082738 @default.
• W2079384071 doi "https://doi.org/10.1111/j.1365-2249.2006.03241.x" @default.
• W2079384071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1810457" @default.
• W2079384071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17177973" @default.
• W2079384071 hasPublicationYear "2006" @default.
• W2079384071 type Work @default.
• W2079384071 sameAs 2079384071 @default.
• W2079384071 citedByCount "14" @default.
• W2079384071 countsByYear W20793840712012 @default.
• W2079384071 countsByYear W20793840712014 @default.
• W2079384071 countsByYear W20793840712015 @default.
• W2079384071 countsByYear W20793840712016 @default.
• W2079384071 countsByYear W20793840712017 @default.
• W2079384071 countsByYear W20793840712020 @default.
• W2079384071 countsByYear W20793840712022 @default.
• W2079384071 countsByYear W20793840712023 @default.
• W2079384071 crossrefType "journal-article" @default.
• W2079384071 hasAuthorship W2079384071A5007007507 @default.
• W2079384071 hasAuthorship W2079384071A5019457819 @default.
• W2079384071 hasAuthorship W2079384071A5020830882 @default.
• W2079384071 hasAuthorship W2079384071A5021028530 @default.
• W2079384071 hasAuthorship W2079384071A5021286534 @default.
• W2079384071 hasAuthorship W2079384071A5039171975 @default.
• W2079384071 hasAuthorship W2079384071A5057845652 @default.
• W2079384071 hasAuthorship W2079384071A5059160872 @default.
• W2079384071 hasAuthorship W2079384071A5080770856 @default.
• W2079384071 hasBestOaLocation W20793840711 @default.
• W2079384071 hasConcept C109316439 @default.
• W2079384071 hasConcept C154317977 @default.
• W2079384071 hasConcept C182615771 @default.
• W2079384071 hasConcept C191732599 @default.
• W2079384071 hasConcept C202751555 @default.
• W2079384071 hasConcept C203014093 @default.
• W2079384071 hasConcept C2522874641 @default.
• W2079384071 hasConcept C2778690821 @default.
• W2079384071 hasConcept C2779823659 @default.
• W2079384071 hasConcept C2780695269 @default.
• W2079384071 hasConcept C55493867 @default.
• W2079384071 hasConcept C86803240 @default.
• W2079384071 hasConcept C8891405 @default.
• W2079384071 hasConceptScore W2079384071C109316439 @default.
• W2079384071 hasConceptScore W2079384071C154317977 @default.
• W2079384071 hasConceptScore W2079384071C182615771 @default.
• W2079384071 hasConceptScore W2079384071C191732599 @default.
• W2079384071 hasConceptScore W2079384071C202751555 @default.
• W2079384071 hasConceptScore W2079384071C203014093 @default.
• W2079384071 hasConceptScore W2079384071C2522874641 @default.
• W2079384071 hasConceptScore W2079384071C2778690821 @default.
• W2079384071 hasConceptScore W2079384071C2779823659 @default.
• W2079384071 hasConceptScore W2079384071C2780695269 @default.
• W2079384071 hasConceptScore W2079384071C55493867 @default.
• W2079384071 hasConceptScore W2079384071C86803240 @default.
• W2079384071 hasConceptScore W2079384071C8891405 @default.
• W2079384071 hasIssue "1" @default.
• W2079384071 hasLocation W20793840711 @default.

• next