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• W2079384587 startingPage "333" @default.
• W2079384587 abstract "Interaction of the Alzheimer’s Aβ peptides with the plasma membrane of cells in culture results in chronic increases in cytosolic [Ca2+]. Such increases can cause a variety of secondary effects leading to impaired cell growth or cell degeneration. In this investigation, we made a comprehensive study of the changes in cytosolic [Ca2+] in single PC12 cells and human neurons stressed by continuous exposure to a medium containing Aβ42 for several days. The differential timing and magnitude of the Aβ42-induced increase in [Ca2+] reveal subpopulations of cells with differential sensitivity to Aβ42. These results suggest that the effect produced by Aβ on the level of cytosolic [Ca2+] depends on the type of cell being monitored. Moreover, the results obtained of using potent inhibitors of Aβ cation channels such as Zn2+ and the small peptide NA7 add further proof to the suggestion that the long-term increases in cytosolic [Ca2+] in cells stressed by continuous exposure to Aβ is the result of Aβ ion channel activity." @default.
• W2079384587 created "2016-06-24" @default.
• W2079384587 creator A5034755455 @default.
• W2079384587 creator A5073174410 @default.
• W2079384587 date "2014-11-01" @default.
• W2079384587 modified "2023-09-27" @default.
• W2079384587 title "Single-cell screening of cytosolic [Ca2+] reveals cell-selective action by the Alzheimer’s Aβ peptide ion channel" @default.
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• W2079384587 doi "https://doi.org/10.1007/s12192-014-0551-2" @default.
• W2079384587 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4326387" @default.
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• W2079384587 hasPublicationYear "2014" @default.
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