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- W2079392489 abstract "A reciprocal translocation between the q arm of the Y chromosome and the q arm of chromosome 14 was identified in a young, phenotypically normal boar presenting azoospermia. Testicular biopsies were analyzed by classical histological and immunolocalization techniques, and by fluorescence in situ hybridization. Meiotic pairing analysis of 85 pachytene spreads showed the presence of an open structure corresponding to a quadrivalent formed by chromosomes 14, X, and the derivative chromosomes 14 and Y in 84.7% of the cases. In the remaining cases (15.3%), a ‘trivalent plus univalent’ configuration was observed. Immunolocalization of γH2AX revealed the presence of this modified histone in the chromatin domains of unsynapsed segments (centromeric region of chromosome 14) and spreading of the γH2AX signal from the XY body throughout chromosome 14 in 7.05% of the cells analyzed. The potential causes of the observed infertility, i.e. activation of meiotic checkpoints and/or silencing of genes necessary for the progression of meiosis, are discussed." @default.
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- W2079392489 date "2008-01-01" @default.
- W2079392489 modified "2023-09-25" @default.
- W2079392489 title "Meiotic studies in an azoospermic boar carrying a Y;14 translocation" @default.
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- W2079392489 doi "https://doi.org/10.1159/000118747" @default.
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