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- W2079394706 abstract "The vertebrate ovary represents a uniquely dynamic organ system charged with the responsibility to initially provide, and subsequently foster, optimal numbers of maturing, viable gametes that will insure the propagation of the species. Seemingly in spite of this charge, >99% of germ cells within the ovaries of mammalian and avian species present at the time of birth or hatch are lost via atresia at some point during the lifespan of the female. The consequence of this ongoing germ cell and ovarian follicle attrition in some species eventually leads to the natural termination of reproductive function (e.g. menopause in humans), while in all species an excessive loss of germ cells frequently results in diminished reproductive potential due to subclinical or clinical infertility. Apoptosis represents the primary pathway by which defective or excessive numbers of follicles are rapidly and effectively eliminated, and this process is actively opposed or entirely suppressed by a variety of cell survival signaling pathways and cellular anti-apoptotic proteins expressed within follicles destined for ovulation. Significantly, such survival mechanisms are regulated by many of the same endocrine-paracrine-autocrine factors that control follicle differentiation. This review will begin by briefly discussing the process of apoptosis, then focus on the varied and often redundant mechanisms that prevent apoptotic cell death in granulosa cells specifically during the late preantral (comparable to the prehierarchal stage of follicle development in avian species) and preovulatory stages of follicle development." @default.
- W2079394706 created "2016-06-24" @default.
- W2079394706 creator A5061205384 @default.
- W2079394706 date "2003-10-01" @default.
- W2079394706 modified "2023-09-25" @default.
- W2079394706 title "Intracellular mechanisms regulating cell survival in ovarian follicles" @default.
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- W2079394706 cites W1965562699 @default.
- W2079394706 cites W1967460751 @default.
- W2079394706 cites W1971297283 @default.
- W2079394706 cites W1972636570 @default.
- W2079394706 cites W1979139420 @default.
- W2079394706 cites W1980640220 @default.
- W2079394706 cites W1981209762 @default.
- W2079394706 cites W1981932258 @default.
- W2079394706 cites W1992460461 @default.
- W2079394706 cites W2005901552 @default.
- W2079394706 cites W2007530728 @default.
- W2079394706 cites W2008390304 @default.
- W2079394706 cites W2020851589 @default.
- W2079394706 cites W2024306318 @default.
- W2079394706 cites W2030710039 @default.
- W2079394706 cites W2033859557 @default.
- W2079394706 cites W2035465800 @default.
- W2079394706 cites W2035759432 @default.
- W2079394706 cites W2049608177 @default.
- W2079394706 cites W2055946816 @default.
- W2079394706 cites W2069579599 @default.
- W2079394706 cites W2072627429 @default.
- W2079394706 cites W2088218587 @default.
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- W2079394706 cites W2116363884 @default.
- W2079394706 cites W2119800239 @default.
- W2079394706 cites W2121575247 @default.
- W2079394706 cites W2127479913 @default.
- W2079394706 cites W2130892384 @default.
- W2079394706 cites W2132964461 @default.
- W2079394706 cites W2138946240 @default.
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- W2079394706 cites W2144876335 @default.
- W2079394706 cites W2146303965 @default.
- W2079394706 cites W2147114673 @default.
- W2079394706 cites W2147309044 @default.
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- W2079394706 cites W2150536749 @default.
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- W2079394706 cites W2167490100 @default.
- W2079394706 cites W2180762163 @default.
- W2079394706 cites W2181430872 @default.
- W2079394706 cites W347349126 @default.
- W2079394706 cites W4230268220 @default.
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- W2079394706 cites W4231374737 @default.
- W2079394706 cites W4231977584 @default.
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- W2079394706 cites W4239684881 @default.
- W2079394706 cites W4240048561 @default.
- W2079394706 cites W4242456250 @default.
- W2079394706 cites W4242536674 @default.
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- W2079394706 cites W4244071538 @default.
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- W2079394706 cites W4248418290 @default.
- W2079394706 cites W4251281471 @default.
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- W2079394706 doi "https://doi.org/10.1016/s0378-4320(03)00090-3" @default.
- W2079394706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12818644" @default.
- W2079394706 hasPublicationYear "2003" @default.
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