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• W2079394987 startingPage "18484" @default.
• W2079394987 abstract "Melatonin is an endogenously produced indoleamine and secreted by the pineal gland. Melatonin has pleiotropic bioactivities and is involved in epigenetic regulation. Suboptimal conditions during maternal and perinatal phases can elicit epigenetic regulation of genes for nephrogenesis and reset physiological responses to develop programmed hypertension. This review discusses the early utility of melatonin to prevent programmed hypertension in later life by epigenetic regulation in the kidney, with an emphasis on: (1) the role of melatonin in epigenetic regulation; (2) the beneficial effects of melatonin on programmed hypertension; (3) epigenetic regulation of maternal melatonin therapy in different developmental windows of offspring kidneys analyzed by whole-genome RNA next-generation sequencing; and (4) current blocks in the application of melatonin in preventing programmed hypertension." @default.
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• W2079394987 date "2014-10-14" @default.
• W2079394987 modified "2023-09-23" @default.
• W2079394987 title "Transcriptional Regulation of Programmed Hypertension by Melatonin: An Epigenetic Perspective" @default.
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• W2079394987 doi "https://doi.org/10.3390/ijms151018484" @default.
• W2079394987 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4227227" @default.
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