FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079399560> ?p ?o ?g. }

• W2079399560 endingPage "67" @default.
• W2079399560 startingPage "60" @default.
• W2079399560 abstract "The immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO) is activated by interferon-gamma (IFN-gamma) and via tryptophan depletion, suppresses adaptive T cell-mediated immunity in inflammation, host immune defense, and maternal tolerance. Its role in solid organ transplantation is still unclear. Therefore, we investigated the usefulness of IDO-mediated tryptophan catabolism in the evaluation of kidney allograft rejection. Blood, urine, and tissue samples were collected from 34 renal transplant patients without rejection and from nine patients with biopsy-confirmed episodes of acute rejection (n=12). Concentrations of kynurenine and tryptophan in serum and urine were analyzed by high-pressure liquid chromatography. Kynurenine to tryptophan ratio (kyn/trp) was calculated to estimate IDO activity. Immunostaining for IDO was performed on renal biopsies. Neopterin was assessed using radioimmunoassay. Kyn/trp and neopterin were detectable at low levels in serum of healthy volunteers and were increased in non-rejecting allograft recipients. Serum levels of kyn/trp were higher in recipients with rejection compared to non-rejectors as early as by day 1 post-surgery. Rejection episodes occurring within 13+/-5.9 days after transplantation were accompanied by elevated kyn/trp in serum (114+/-44.5 micromol/mmol, P=0.001) and urine (126+/-65.9 micromol/mmol, P=0.02) compared to levels during stable graft function. Kyn/trp correlated significantly with neopterin suggesting an IFN-gamma-induced increase in IDO activity. Immunostaining showed upregulation of IDO in rejection biopsies, localized in tubular-epithelial cells. Non-rejected grafts displayed no IDO expression. Acute rejection is associated with simultaneously increased serum and urinary kyn/trp in patients after kidney transplantation. Thus, IDO activity might offer a novel non-invasive means of immunomonitoring of renal allografts." @default.
• W2079399560 created "2016-06-24" @default.
• W2079399560 creator A5024222977 @default.
• W2079399560 creator A5028165343 @default.
• W2079399560 creator A5035603410 @default.
• W2079399560 creator A5049490668 @default.
• W2079399560 creator A5054471282 @default.
• W2079399560 creator A5055808022 @default.
• W2079399560 creator A5074805124 @default.
• W2079399560 creator A5081156604 @default.
• W2079399560 creator A5085570874 @default.
• W2079399560 creator A5087266179 @default.
• W2079399560 creator A5087598341 @default.
• W2079399560 date "2007-01-01" @default.
• W2079399560 modified "2023-10-10" @default.
• W2079399560 title "Non-invasive monitoring of kidney allograft rejection through IDO metabolism evaluation" @default.
• W2079399560 cites W1627869463 @default.
• W2079399560 cites W1925988920 @default.
• W2079399560 cites W1964609124 @default.
• W2079399560 cites W1966656379 @default.
• W2079399560 cites W1967257073 @default.
• W2079399560 cites W1974130599 @default.
• W2079399560 cites W1974401900 @default.
• W2079399560 cites W1979296983 @default.
• W2079399560 cites W1981961784 @default.
• W2079399560 cites W1987171603 @default.
• W2079399560 cites W1997894427 @default.
• W2079399560 cites W2004806121 @default.
• W2079399560 cites W2005571837 @default.
• W2079399560 cites W2008893382 @default.
• W2079399560 cites W2013823918 @default.
• W2079399560 cites W2015260577 @default.
• W2079399560 cites W2022430924 @default.
• W2079399560 cites W2037920661 @default.
• W2079399560 cites W2038012068 @default.
• W2079399560 cites W2041978494 @default.
• W2079399560 cites W2046986477 @default.
• W2079399560 cites W2051839360 @default.
• W2079399560 cites W2055523179 @default.
• W2079399560 cites W2056093579 @default.
• W2079399560 cites W2071922368 @default.
• W2079399560 cites W2080217598 @default.
• W2079399560 cites W2083380291 @default.
• W2079399560 cites W2084622238 @default.
• W2079399560 cites W2085539230 @default.
• W2079399560 cites W2086002861 @default.
• W2079399560 cites W2092524794 @default.
• W2079399560 cites W2100415101 @default.
• W2079399560 cites W2102942510 @default.
• W2079399560 cites W2107346812 @default.
• W2079399560 cites W2108086513 @default.
• W2079399560 cites W2138122208 @default.
• W2079399560 cites W2146934919 @default.
• W2079399560 cites W2152857351 @default.
• W2079399560 cites W2160827995 @default.
• W2079399560 cites W2170264508 @default.
• W2079399560 doi "https://doi.org/10.1038/sj.ki.5002023" @default.
• W2079399560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17136028" @default.
• W2079399560 hasPublicationYear "2007" @default.
• W2079399560 type Work @default.
• W2079399560 sameAs 2079399560 @default.
• W2079399560 citedByCount "96" @default.
• W2079399560 countsByYear W20793995602012 @default.
• W2079399560 countsByYear W20793995602013 @default.
• W2079399560 countsByYear W20793995602014 @default.
• W2079399560 countsByYear W20793995602015 @default.
• W2079399560 countsByYear W20793995602016 @default.
• W2079399560 countsByYear W20793995602017 @default.
• W2079399560 countsByYear W20793995602018 @default.
• W2079399560 countsByYear W20793995602019 @default.
• W2079399560 countsByYear W20793995602020 @default.
• W2079399560 countsByYear W20793995602021 @default.
• W2079399560 countsByYear W20793995602022 @default.
• W2079399560 countsByYear W20793995602023 @default.
• W2079399560 crossrefType "journal-article" @default.
• W2079399560 hasAuthorship W2079399560A5024222977 @default.
• W2079399560 hasAuthorship W2079399560A5028165343 @default.
• W2079399560 hasAuthorship W2079399560A5035603410 @default.
• W2079399560 hasAuthorship W2079399560A5049490668 @default.
• W2079399560 hasAuthorship W2079399560A5054471282 @default.
• W2079399560 hasAuthorship W2079399560A5055808022 @default.
• W2079399560 hasAuthorship W2079399560A5074805124 @default.
• W2079399560 hasAuthorship W2079399560A5081156604 @default.
• W2079399560 hasAuthorship W2079399560A5085570874 @default.
• W2079399560 hasAuthorship W2079399560A5087266179 @default.
• W2079399560 hasAuthorship W2079399560A5087598341 @default.
• W2079399560 hasBestOaLocation W20793995601 @default.
• W2079399560 hasConcept C126322002 @default.
• W2079399560 hasConcept C134018914 @default.
• W2079399560 hasConcept C185592680 @default.
• W2079399560 hasConcept C203014093 @default.
• W2079399560 hasConcept C204232928 @default.
• W2079399560 hasConcept C2776603314 @default.
• W2079399560 hasConcept C2776706248 @default.
• W2079399560 hasConcept C2776710720 @default.
• W2079399560 hasConcept C2777503454 @default.
• W2079399560 hasConcept C2780026642 @default.
• W2079399560 hasConcept C2780091579 @default.

• next