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- W2079401244 abstract "Polysaccharide capsules are important virulence factors for many microbial pathogens including the opportunistic fungus Cryptococcus neoformans. In the present study, we demonstrate an unusual role for a secreted lactonohydrolase of C. neoformans, LHC1 in capsular higher order structure. Analysis of extracted capsular polysaccharide from wild-type and lhc1Δ strains by dynamic and static light scattering suggested a role for the LHC1 locus in altering the capsular polysaccharide, both reducing dimensions and altering its branching, density and solvation. These changes in the capsular structure resulted in LHC1-dependent alterations of antibody binding patterns, reductions in human and mouse complement binding and phagocytosis by the macrophage-like cell line J774, as well as increased virulence in mice. These findings identify a unique molecular mechanism for tertiary structural changes in a microbial capsule, facilitating immune evasion and virulence of a fungal pathogen." @default.
- W2079401244 created "2016-06-24" @default.
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- W2079401244 date "2014-05-01" @default.
- W2079401244 modified "2023-10-11" @default.
- W2079401244 title "A Role for LHC1 in Higher Order Structure and Complement Binding of the Cryptococcus neoformans Capsule" @default.
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- W2079401244 doi "https://doi.org/10.1371/journal.ppat.1004037" @default.
- W2079401244 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4006888" @default.
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