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- W2079402279 abstract "Background: Concerning myopathies, the treatment of myocardial impairment raises specific issues due to the structure and function of the myocardium. Thus, original routes of administration can be considered as direct injection into the myocardium, coronary infusion or intrapericardial injection. Gene therapy is mainly based on two different vector systems: viral or non-viral formulation of the DNA. Considering that repeated administrations of plasmid DNA (pDNA) would be mandatory to achieve the therapeutic goals and that viral transfection's main issue remains immunogenicity, non-viral vectors seem to be the best suited. Several lipidic or polymeric systems have already been tested, and in vivo, one of the most efficient appears to be polyethyleneimine (PEI). Our study aims at designing a new non-viral system for myocardial gene delivery, displaying low toxicity and the best efficiency. This system is based on condensation of plasmid DNA with PEI. These polyplexes are then included in a thermosensitive gel in order to improve the residence time of the system and administered via the intrapericardial route." @default.
- W2079402279 created "2016-06-24" @default.
- W2079402279 date "2005-05-01" @default.
- W2079402279 modified "2023-09-26" @default.
- W2079402279 title "229. Development of a Novel Drug Delivery System Based on Intrapericardial Administration of Plasmid DNA in a Thermosensitive Gel Formulation" @default.
- W2079402279 doi "https://doi.org/10.1016/j.ymthe.2005.06.232" @default.
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