FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079403338> ?p ?o ?g. }

• W2079403338 endingPage "43" @default.
• W2079403338 startingPage "36" @default.
• W2079403338 abstract "The present electric shock (ES) schedule followed in these experiments produced different functional changes in endogenous putative opioid agonist- and antagonist-type receptors, depending on the type of receptor: the amount of antagonist binding was increased by ES application, while the amount of agonist binding was decreased. In order to elucidate the mechanism of these changes, we investigated whether ES application was able to affect sulfhydryl-groups and phospholipids of endogenous opioid receptors. In comparison to the control membrane, the increased antagonist binding sites of the ES membrane were liable to be inactivated by the sulfhydryl-modifying reagents, N-ethylmaleimide (NEM) and iodoacetamide. However, in the presence of 100 mM Na, the antagonist binding sites of both the control and ES membranes were inactivated by NEM in the same manner. On the other hand, the agonist binding sites of both membranes were similarly inactivated by NEM regardless of the absence or presence of 100 mM Na. Another sulfhydryl-modifying reagent, such as p-chloromercuriphenylsulfonic acid, did not produce any difference between the control and ES membranes. The increased antagonist binding sites of the ES membrane were also liable to be inactivated by phospholipase A2. These results suggest that the present ES schedule followed in these experiments produces conformational changes in endogenous opioid receptors in the rat brain. As a result of these conformational changes, the amount of binding in the antagonist sites may be increased, while the amount of binding in the agonist sites may be decreased. However, the increased antagonist binding sites may be liable to be inactivated by NEM, iodoacetamide and phospholipase A2." @default.
• W2079403338 created "2016-06-24" @default.
• W2079403338 creator A5055747865 @default.
• W2079403338 creator A5070206132 @default.
• W2079403338 creator A5089387849 @default.
• W2079403338 date "1985-09-01" @default.
• W2079403338 modified "2023-10-17" @default.
• W2079403338 title "Conformational changes of opioid receptor induced by the electric footshock" @default.
• W2079403338 cites W1643360359 @default.
• W2079403338 cites W1775749144 @default.
• W2079403338 cites W1971186982 @default.
• W2079403338 cites W1972035961 @default.
• W2079403338 cites W1972485079 @default.
• W2079403338 cites W1979385488 @default.
• W2079403338 cites W1979569718 @default.
• W2079403338 cites W1980165431 @default.
• W2079403338 cites W1988412488 @default.
• W2079403338 cites W1993993935 @default.
• W2079403338 cites W1998044137 @default.
• W2079403338 cites W2004189259 @default.
• W2079403338 cites W2010644776 @default.
• W2079403338 cites W2015863188 @default.
• W2079403338 cites W2017239164 @default.
• W2079403338 cites W2020614462 @default.
• W2079403338 cites W2023620032 @default.
• W2079403338 cites W2025319187 @default.
• W2079403338 cites W2025631787 @default.
• W2079403338 cites W2032527635 @default.
• W2079403338 cites W2035881669 @default.
• W2079403338 cites W2037437115 @default.
• W2079403338 cites W2046407711 @default.
• W2079403338 cites W2058558193 @default.
• W2079403338 cites W2061758223 @default.
• W2079403338 cites W2063555058 @default.
• W2079403338 cites W2068207038 @default.
• W2079403338 cites W2072804266 @default.
• W2079403338 cites W2076664815 @default.
• W2079403338 cites W2086213161 @default.
• W2079403338 cites W2102420653 @default.
• W2079403338 cites W2136656184 @default.
• W2079403338 doi "https://doi.org/10.1016/0006-8993(85)91155-2" @default.
• W2079403338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2994830" @default.
• W2079403338 hasPublicationYear "1985" @default.
• W2079403338 type Work @default.
• W2079403338 sameAs 2079403338 @default.
• W2079403338 citedByCount "9" @default.
• W2079403338 crossrefType "journal-article" @default.
• W2079403338 hasAuthorship W2079403338A5055747865 @default.
• W2079403338 hasAuthorship W2079403338A5070206132 @default.
• W2079403338 hasAuthorship W2079403338A5089387849 @default.
• W2079403338 hasConcept C107824862 @default.
• W2079403338 hasConcept C12554922 @default.
• W2079403338 hasConcept C16613235 @default.
• W2079403338 hasConcept C170493617 @default.
• W2079403338 hasConcept C181199279 @default.
• W2079403338 hasConcept C185592680 @default.
• W2079403338 hasConcept C2775962371 @default.
• W2079403338 hasConcept C2776515853 @default.
• W2079403338 hasConcept C2776885963 @default.
• W2079403338 hasConcept C2778539182 @default.
• W2079403338 hasConcept C2778750930 @default.
• W2079403338 hasConcept C2778938600 @default.
• W2079403338 hasConcept C2779201268 @default.
• W2079403338 hasConcept C2779886867 @default.
• W2079403338 hasConcept C41625074 @default.
• W2079403338 hasConcept C55493867 @default.
• W2079403338 hasConcept C86803240 @default.
• W2079403338 hasConcept C86811712 @default.
• W2079403338 hasConcept C98274493 @default.
• W2079403338 hasConceptScore W2079403338C107824862 @default.
• W2079403338 hasConceptScore W2079403338C12554922 @default.
• W2079403338 hasConceptScore W2079403338C16613235 @default.
• W2079403338 hasConceptScore W2079403338C170493617 @default.
• W2079403338 hasConceptScore W2079403338C181199279 @default.
• W2079403338 hasConceptScore W2079403338C185592680 @default.
• W2079403338 hasConceptScore W2079403338C2775962371 @default.
• W2079403338 hasConceptScore W2079403338C2776515853 @default.
• W2079403338 hasConceptScore W2079403338C2776885963 @default.
• W2079403338 hasConceptScore W2079403338C2778539182 @default.
• W2079403338 hasConceptScore W2079403338C2778750930 @default.
• W2079403338 hasConceptScore W2079403338C2778938600 @default.
• W2079403338 hasConceptScore W2079403338C2779201268 @default.
• W2079403338 hasConceptScore W2079403338C2779886867 @default.
• W2079403338 hasConceptScore W2079403338C41625074 @default.
• W2079403338 hasConceptScore W2079403338C55493867 @default.
• W2079403338 hasConceptScore W2079403338C86803240 @default.
• W2079403338 hasConceptScore W2079403338C86811712 @default.
• W2079403338 hasConceptScore W2079403338C98274493 @default.
• W2079403338 hasIssue "1" @default.
• W2079403338 hasLocation W20794033381 @default.
• W2079403338 hasLocation W20794033382 @default.
• W2079403338 hasOpenAccess W2079403338 @default.
• W2079403338 hasPrimaryLocation W20794033381 @default.
• W2079403338 hasRelatedWork W1975774803 @default.
• W2079403338 hasRelatedWork W1979368316 @default.
• W2079403338 hasRelatedWork W1985649660 @default.
• W2079403338 hasRelatedWork W1988429857 @default.
• W2079403338 hasRelatedWork W2033874747 @default.

• next