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- W2079403533 abstract "Iron overload diseases of genetic origin are an ever changing world, due to major advances in genetics and molecular biology. Five major categories are now established: HFE-related or type1 hemochromatosis, frequently found in Caucasians, and four rarer diseases which are type 2 (A and B) hemochromatosis (juvenile hemochromatosis), type 3 hemochromatosis (transferrin receptor 2 hemochromatosis), type 4 (A and B) hemochromatosis (ferroportin disease), and a(hypo)ceruloplasminemia. Increased duodenal iron absorption and enhanced macrophagic iron recycling, both due to an impairment of hepcidin synthesis, account for the development of cellular excess in types 1, 2, 3, and 4B hemochromatosis whereas decreased cellular iron egress is involved in the main form of type 4A) hemochromatosis and in aceruloplasminemia. Non-transferrin bound iron plays an important role in cellular iron excess and damage. The combination of magnetic resonance imaging (for diagnosing visceral iron overload) and of genetic testing has drastically reduced the need for liver biopsy. Phlebotomies remain an essential therapeutic tool but the improved understanding of the intimate mechanisms underlying these diseases paves the road for innovative therapeutic approaches." @default.
- W2079403533 created "2016-06-24" @default.
- W2079403533 creator A5022945624 @default.
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- W2079403533 date "2008-07-01" @default.
- W2079403533 modified "2023-10-17" @default.
- W2079403533 title "Current approach to hemochromatosis" @default.
- W2079403533 cites W1504293485 @default.
- W2079403533 cites W1522974031 @default.
- W2079403533 cites W1564092073 @default.
- W2079403533 cites W1568359313 @default.
- W2079403533 cites W1593003780 @default.
- W2079403533 cites W1604045140 @default.
- W2079403533 cites W1761222131 @default.
- W2079403533 cites W1964374032 @default.
- W2079403533 cites W1964842418 @default.
- W2079403533 cites W1965294240 @default.
- W2079403533 cites W1966778627 @default.
- W2079403533 cites W1967648231 @default.
- W2079403533 cites W1975695761 @default.
- W2079403533 cites W1976726664 @default.
- W2079403533 cites W1980042430 @default.
- W2079403533 cites W1981499088 @default.
- W2079403533 cites W1983970155 @default.
- W2079403533 cites W1984960613 @default.
- W2079403533 cites W1986840089 @default.
- W2079403533 cites W1987057326 @default.
- W2079403533 cites W1988150327 @default.
- W2079403533 cites W1997462858 @default.
- W2079403533 cites W2002605005 @default.
- W2079403533 cites W2002986792 @default.
- W2079403533 cites W2010746593 @default.
- W2079403533 cites W2014425812 @default.
- W2079403533 cites W2017722157 @default.
- W2079403533 cites W2018430903 @default.
- W2079403533 cites W2023025787 @default.
- W2079403533 cites W2025063713 @default.
- W2079403533 cites W2027503473 @default.
- W2079403533 cites W2029443758 @default.
- W2079403533 cites W2032533705 @default.
- W2079403533 cites W2034696230 @default.
- W2079403533 cites W2035390231 @default.
- W2079403533 cites W2038944724 @default.
- W2079403533 cites W2041030349 @default.
- W2079403533 cites W2041715899 @default.
- W2079403533 cites W2041834919 @default.
- W2079403533 cites W2043831336 @default.
- W2079403533 cites W2047018225 @default.
- W2079403533 cites W2048706423 @default.
- W2079403533 cites W2050833520 @default.
- W2079403533 cites W2051747959 @default.
- W2079403533 cites W2051778940 @default.
- W2079403533 cites W2054060736 @default.
- W2079403533 cites W2054421541 @default.
- W2079403533 cites W2056149198 @default.
- W2079403533 cites W2056282179 @default.
- W2079403533 cites W2056780690 @default.
- W2079403533 cites W2058620081 @default.
- W2079403533 cites W2059080581 @default.
- W2079403533 cites W2062638934 @default.
- W2079403533 cites W2063102842 @default.
- W2079403533 cites W2064625754 @default.
- W2079403533 cites W2064708319 @default.
- W2079403533 cites W2068337287 @default.
- W2079403533 cites W2072738759 @default.
- W2079403533 cites W2074000647 @default.
- W2079403533 cites W2074819870 @default.
- W2079403533 cites W2075160485 @default.
- W2079403533 cites W2077326136 @default.
- W2079403533 cites W2080946483 @default.
- W2079403533 cites W2081605227 @default.
- W2079403533 cites W2082614132 @default.
- W2079403533 cites W2088475546 @default.
- W2079403533 cites W2088903681 @default.
- W2079403533 cites W2090165219 @default.
- W2079403533 cites W2091806624 @default.
- W2079403533 cites W2094486173 @default.
- W2079403533 cites W2095232221 @default.
- W2079403533 cites W2096737179 @default.
- W2079403533 cites W2097405210 @default.
- W2079403533 cites W2099286385 @default.
- W2079403533 cites W2101093867 @default.
- W2079403533 cites W2103443696 @default.
- W2079403533 cites W2107423980 @default.
- W2079403533 cites W2107528506 @default.
- W2079403533 cites W2108344872 @default.
- W2079403533 cites W2108759348 @default.
- W2079403533 cites W2109672821 @default.
- W2079403533 cites W2116064842 @default.
- W2079403533 cites W2119692077 @default.
- W2079403533 cites W2120359196 @default.
- W2079403533 cites W2121306800 @default.
- W2079403533 cites W2123598093 @default.