Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079405009> ?p ?o ?g. }
- W2079405009 endingPage "3196" @default.
- W2079405009 startingPage "3190" @default.
- W2079405009 abstract "The neuropeptide galanin is expressed in sympathetic nerve terminals that surround islet cells and inhibits insulin secretion. To explore its role for islet function, we studied mice with a loss-of-function mutation in the galanin gene [galanin knockout (KO) mice]. Intravenous 2-deoxy-glucose, which activates both the sympathetic and parasympathetic branches of the autonomic nervous system, caused an initial (1-5 min) inhibition of insulin secretion that was impaired in galanin KO mice (P = 0.027), followed by a subsequent stimulation of insulin secretion that was augmented in galanin KO mice (P < 0.01). Similar effects were seen after chemical sympathectomy by 6-hydroxydopamine. In contrast, galanin KO mice had a reduced insulin response to glucose, both in vivo (P < 0.001) and in isolated islets (P < 0.001), and to arginine, both in vivo (P = 0.012) and in vitro (P = 0.018). During an iv glucose tolerance test, galanin KO mice had impaired glucose disposal (P = 0.005) due to a reduced insulin response (P < 0.001) and a reduced insulin-independent glucose elimination (glucose effectiveness; P = 0.040). Insulin sensitivity, as judged by a euglycemic, hyperinsulinemic clamp technique, was slightly increased in galanin KO mice (P = 0.032). We conclude that 1) galanin may contribute to sympathetic influences inhibiting insulin secretion in mice, and 2) galanin KO mice have a reduced glucose-induced insulin secretion." @default.
- W2079405009 created "2016-06-24" @default.
- W2079405009 creator A5014848806 @default.
- W2079405009 creator A5027109387 @default.
- W2079405009 creator A5054707430 @default.
- W2079405009 creator A5062796762 @default.
- W2079405009 creator A5068418631 @default.
- W2079405009 date "2004-07-01" @default.
- W2079405009 modified "2023-09-26" @default.
- W2079405009 title "Loss-of-Function Mutation of the Galanin Gene Is Associated with Perturbed Islet Function in Mice" @default.
- W2079405009 cites W186774716 @default.
- W2079405009 cites W1986071903 @default.
- W2079405009 cites W1991621273 @default.
- W2079405009 cites W1992399074 @default.
- W2079405009 cites W2009239846 @default.
- W2079405009 cites W2010271232 @default.
- W2079405009 cites W2013928632 @default.
- W2079405009 cites W2015920050 @default.
- W2079405009 cites W2016846560 @default.
- W2079405009 cites W2017208463 @default.
- W2079405009 cites W2017482634 @default.
- W2079405009 cites W2021243398 @default.
- W2079405009 cites W2033306867 @default.
- W2079405009 cites W2039246060 @default.
- W2079405009 cites W2053429084 @default.
- W2079405009 cites W2056284360 @default.
- W2079405009 cites W2060552805 @default.
- W2079405009 cites W2061309116 @default.
- W2079405009 cites W2075962195 @default.
- W2079405009 cites W2077070505 @default.
- W2079405009 cites W2081318242 @default.
- W2079405009 cites W2092356595 @default.
- W2079405009 cites W2105748867 @default.
- W2079405009 cites W2116121618 @default.
- W2079405009 cites W2121357668 @default.
- W2079405009 cites W2135600240 @default.
- W2079405009 cites W2149480053 @default.
- W2079405009 cites W2150638669 @default.
- W2079405009 cites W2153058082 @default.
- W2079405009 cites W2156657510 @default.
- W2079405009 cites W2165785647 @default.
- W2079405009 cites W2335980015 @default.
- W2079405009 cites W287203130 @default.
- W2079405009 doi "https://doi.org/10.1210/en.2003-1700" @default.
- W2079405009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15044363" @default.
- W2079405009 hasPublicationYear "2004" @default.
- W2079405009 type Work @default.
- W2079405009 sameAs 2079405009 @default.
- W2079405009 citedByCount "67" @default.
- W2079405009 countsByYear W20794050092012 @default.
- W2079405009 countsByYear W20794050092013 @default.
- W2079405009 countsByYear W20794050092014 @default.
- W2079405009 countsByYear W20794050092015 @default.
- W2079405009 countsByYear W20794050092016 @default.
- W2079405009 countsByYear W20794050092017 @default.
- W2079405009 countsByYear W20794050092018 @default.
- W2079405009 countsByYear W20794050092019 @default.
- W2079405009 countsByYear W20794050092020 @default.
- W2079405009 countsByYear W20794050092021 @default.
- W2079405009 countsByYear W20794050092022 @default.
- W2079405009 countsByYear W20794050092023 @default.
- W2079405009 crossrefType "journal-article" @default.
- W2079405009 hasAuthorship W2079405009A5014848806 @default.
- W2079405009 hasAuthorship W2079405009A5027109387 @default.
- W2079405009 hasAuthorship W2079405009A5054707430 @default.
- W2079405009 hasAuthorship W2079405009A5062796762 @default.
- W2079405009 hasAuthorship W2079405009A5068418631 @default.
- W2079405009 hasBestOaLocation W20794050091 @default.
- W2079405009 hasConcept C118303440 @default.
- W2079405009 hasConcept C126322002 @default.
- W2079405009 hasConcept C134018914 @default.
- W2079405009 hasConcept C165220095 @default.
- W2079405009 hasConcept C170493617 @default.
- W2079405009 hasConcept C19519825 @default.
- W2079405009 hasConcept C2777391703 @default.
- W2079405009 hasConcept C2779306644 @default.
- W2079405009 hasConcept C3018667095 @default.
- W2079405009 hasConcept C71924100 @default.
- W2079405009 hasConcept C86803240 @default.
- W2079405009 hasConceptScore W2079405009C118303440 @default.
- W2079405009 hasConceptScore W2079405009C126322002 @default.
- W2079405009 hasConceptScore W2079405009C134018914 @default.
- W2079405009 hasConceptScore W2079405009C165220095 @default.
- W2079405009 hasConceptScore W2079405009C170493617 @default.
- W2079405009 hasConceptScore W2079405009C19519825 @default.
- W2079405009 hasConceptScore W2079405009C2777391703 @default.
- W2079405009 hasConceptScore W2079405009C2779306644 @default.
- W2079405009 hasConceptScore W2079405009C3018667095 @default.
- W2079405009 hasConceptScore W2079405009C71924100 @default.
- W2079405009 hasConceptScore W2079405009C86803240 @default.
- W2079405009 hasIssue "7" @default.
- W2079405009 hasLocation W20794050091 @default.
- W2079405009 hasLocation W20794050092 @default.
- W2079405009 hasOpenAccess W2079405009 @default.
- W2079405009 hasPrimaryLocation W20794050091 @default.
- W2079405009 hasRelatedWork W1577371918 @default.
- W2079405009 hasRelatedWork W1973049774 @default.
- W2079405009 hasRelatedWork W2005183298 @default.