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- W2079405789 abstract "Concanavalin A (Con A)-activated suppressor cells from 4 patients with familial Mediterranean fever (FMF) and 16 normal volunteers were tested for suppression of proliferation of phytohemagglutinin (PHA)-stimulated responder cells from normal volunteers. The mean (±SE) percentage suppression by each FMF patient (4 ± 3, 2 ± 2, 8 ± 3, and 9 ± 4) was significantly (P < 0.0005) less than the mean percentage suppression by 16 normal volunteers (44 ± 4). Cells from 2 of the FMF patients were also tested as responder cells. Con A-activated cells from normal volunteers did not suppress the proliferation of PHA-stimulated responder cells from one of these FMF patients (8%) but did suppress responder cells from the second FMF patient (43%). Furthermore, Con A-activated cells from two milk-allergic patients (suppressing 63% in coculture with responder cells from a normal volunteer) did not suppress responder cells from this second FMF patient (4%). Thus, FMF is associated with two immunoregulatory abnormalities: defective suppressor cell and abnormal responder cell function." @default.
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- W2079405789 date "1981-02-01" @default.
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- W2079405789 title "Immunoregulatory abnormalities in familial Mediterranean fever" @default.
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- W2079405789 doi "https://doi.org/10.1016/0090-1229(81)90032-5" @default.
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