Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079406256> ?p ?o ?g. }
- W2079406256 endingPage "141" @default.
- W2079406256 startingPage "136" @default.
- W2079406256 abstract "The state of aggregation of the polymer melanin may determine its propensity to act either as an antioxidant or as a pro-oxidant. Age-related alterations in its state of aggregation are suggested to alter the degree of polymerization so as to confer increased pro-oxidant propensity to the melanin polymer. Degradative processes in/of melanosomes and lysosomes in the retinal pigment epithelium (RPE) appear to be intimately connected so that they may involve exchange of contents between these two organelles. An increased pro-oxidant environment inside lysosomes has been associated with preventing the digestion of cellular components including photoreceptor outer rod segments partly by altering function of lysosomal hydrolases. It is speculated that age-related accumulation of low-molecular-weight phototoxic pro-oxidant melanin oligomers within lysosomes in the RPE may be partly responsible for decreasing the digestive rate of incorporated cellular components (including photoreceptor outer rod segments) which may lead to lipofuscin formation. More work is required to definitively refute or support such a hypothesis." @default.
- W2079406256 created "2016-06-24" @default.
- W2079406256 creator A5074523903 @default.
- W2079406256 creator A5074830972 @default.
- W2079406256 date "2005-01-01" @default.
- W2079406256 modified "2023-09-23" @default.
- W2079406256 title "Melanin Aggregation and Polymerization: Possible Implications in Age-Related Macular Degeneration" @default.
- W2079406256 cites W1487081220 @default.
- W2079406256 cites W1538904872 @default.
- W2079406256 cites W1967625176 @default.
- W2079406256 cites W1970045389 @default.
- W2079406256 cites W1971221600 @default.
- W2079406256 cites W1972308264 @default.
- W2079406256 cites W1973136271 @default.
- W2079406256 cites W1973221085 @default.
- W2079406256 cites W1980333061 @default.
- W2079406256 cites W1980790707 @default.
- W2079406256 cites W1987685387 @default.
- W2079406256 cites W1993158736 @default.
- W2079406256 cites W1993446288 @default.
- W2079406256 cites W1993742748 @default.
- W2079406256 cites W1993781871 @default.
- W2079406256 cites W2010249931 @default.
- W2079406256 cites W2013852428 @default.
- W2079406256 cites W2016302324 @default.
- W2079406256 cites W2019869152 @default.
- W2079406256 cites W2020640665 @default.
- W2079406256 cites W2022506257 @default.
- W2079406256 cites W2024460557 @default.
- W2079406256 cites W2030090086 @default.
- W2079406256 cites W2031475689 @default.
- W2079406256 cites W2035332838 @default.
- W2079406256 cites W2040645467 @default.
- W2079406256 cites W2042056482 @default.
- W2079406256 cites W2042162229 @default.
- W2079406256 cites W2044594563 @default.
- W2079406256 cites W2044992662 @default.
- W2079406256 cites W2050878478 @default.
- W2079406256 cites W2055913339 @default.
- W2079406256 cites W2056865617 @default.
- W2079406256 cites W2057189144 @default.
- W2079406256 cites W2063073659 @default.
- W2079406256 cites W2063186516 @default.
- W2079406256 cites W2065668797 @default.
- W2079406256 cites W2066671744 @default.
- W2079406256 cites W2067991619 @default.
- W2079406256 cites W2069749707 @default.
- W2079406256 cites W2072792545 @default.
- W2079406256 cites W2080881203 @default.
- W2079406256 cites W2081193771 @default.
- W2079406256 cites W2081647497 @default.
- W2079406256 cites W2092163284 @default.
- W2079406256 cites W2092706340 @default.
- W2079406256 cites W2108050710 @default.
- W2079406256 cites W2108482850 @default.
- W2079406256 cites W2130886586 @default.
- W2079406256 cites W2159058105 @default.
- W2079406256 cites W2315512556 @default.
- W2079406256 cites W2411031570 @default.
- W2079406256 cites W2912179861 @default.
- W2079406256 cites W4236626209 @default.
- W2079406256 doi "https://doi.org/10.1159/000085533" @default.
- W2079406256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15867475" @default.
- W2079406256 hasPublicationYear "2005" @default.
- W2079406256 type Work @default.
- W2079406256 sameAs 2079406256 @default.
- W2079406256 citedByCount "19" @default.
- W2079406256 countsByYear W20794062562012 @default.
- W2079406256 countsByYear W20794062562013 @default.
- W2079406256 countsByYear W20794062562014 @default.
- W2079406256 countsByYear W20794062562015 @default.
- W2079406256 countsByYear W20794062562018 @default.
- W2079406256 countsByYear W20794062562019 @default.
- W2079406256 countsByYear W20794062562021 @default.
- W2079406256 countsByYear W20794062562022 @default.
- W2079406256 countsByYear W20794062562023 @default.
- W2079406256 crossrefType "journal-article" @default.
- W2079406256 hasAuthorship W2079406256A5074523903 @default.
- W2079406256 hasAuthorship W2079406256A5074830972 @default.
- W2079406256 hasConcept C107538193 @default.
- W2079406256 hasConcept C12554922 @default.
- W2079406256 hasConcept C142724271 @default.
- W2079406256 hasConcept C168240541 @default.
- W2079406256 hasConcept C178790620 @default.
- W2079406256 hasConcept C181199279 @default.
- W2079406256 hasConcept C185592680 @default.
- W2079406256 hasConcept C186198217 @default.
- W2079406256 hasConcept C20418707 @default.
- W2079406256 hasConcept C2778004101 @default.
- W2079406256 hasConcept C2778024200 @default.
- W2079406256 hasConcept C2779354088 @default.
- W2079406256 hasConcept C2780216420 @default.
- W2079406256 hasConcept C2780827179 @default.
- W2079406256 hasConcept C44228677 @default.
- W2079406256 hasConcept C521977710 @default.
- W2079406256 hasConcept C55493867 @default.
- W2079406256 hasConcept C71924100 @default.
- W2079406256 hasConcept C86803240 @default.