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- W2079410007 abstract "The initiation and progression of human cancer is frequently linked to the uncontrolled activation of survival kinases. Two such pro-survival kinases that are commonly amplified in cancer are PIM and Akt. These oncogenic proteins are serine/threonine kinases that regulate tumorigenesis by phosphorylating substrates that control the cell cycle, cellular metabolism, proliferation, and survival. Growing evidence suggests that cross-talk exists between the PIM and Akt kinases, indicating that they control partially overlapping survival signaling pathways that are critical to the initiation, progression, and metastatic spread of many types of cancer. The PI3K/Akt signaling pathway is activated in many human tumors, and it is well established as a promising anticancer target. Likewise, based on the role of PIM kinases in normal and tumor tissues, it is clear that this family of kinases represents an interesting target for anticancer therapy. Pharmacological inhibition of PIM has the potential to significantly influence the efficacy of standard and targeted therapies. This review focuses on the regulation of PIM kinases, their role in tumorigenesis, and the biological impact of their interaction with the Akt signaling pathway on the efficacy of cancer therapy." @default.
- W2079410007 created "2016-06-24" @default.
- W2079410007 creator A5086393033 @default.
- W2079410007 creator A5090625332 @default.
- W2079410007 date "2015-07-01" @default.
- W2079410007 modified "2023-10-06" @default.
- W2079410007 title "PIM kinase (and Akt) biology and signaling in tumors" @default.
- W2079410007 cites W1013290308 @default.
- W2079410007 cites W105608943 @default.
- W2079410007 cites W1495346616 @default.
- W2079410007 cites W1500729563 @default.
- W2079410007 cites W1509669696 @default.
- W2079410007 cites W1551136390 @default.
- W2079410007 cites W1588676742 @default.
- W2079410007 cites W1592701464 @default.
- W2079410007 cites W1828246982 @default.
- W2079410007 cites W1857478378 @default.
- W2079410007 cites W1963730114 @default.
- W2079410007 cites W1967320250 @default.
- W2079410007 cites W1967971429 @default.
- W2079410007 cites W1968075576 @default.
- W2079410007 cites W1969675752 @default.
- W2079410007 cites W1969969746 @default.
- W2079410007 cites W1970308473 @default.
- W2079410007 cites W1970701525 @default.
- W2079410007 cites W1971524431 @default.
- W2079410007 cites W1973096179 @default.
- W2079410007 cites W1973500525 @default.
- W2079410007 cites W1973522995 @default.
- W2079410007 cites W1973537366 @default.
- W2079410007 cites W1979035196 @default.
- W2079410007 cites W1979733687 @default.
- W2079410007 cites W1982621240 @default.
- W2079410007 cites W1983887345 @default.
- W2079410007 cites W1984354659 @default.
- W2079410007 cites W1985051375 @default.
- W2079410007 cites W1986375034 @default.
- W2079410007 cites W1987380844 @default.
- W2079410007 cites W1995197723 @default.
- W2079410007 cites W2006368533 @default.
- W2079410007 cites W2008629475 @default.
- W2079410007 cites W2010895681 @default.
- W2079410007 cites W2011810742 @default.
- W2079410007 cites W2014117599 @default.
- W2079410007 cites W2015173256 @default.
- W2079410007 cites W2015202978 @default.
- W2079410007 cites W2015390918 @default.
- W2079410007 cites W2015714994 @default.
- W2079410007 cites W2017366419 @default.
- W2079410007 cites W2017437933 @default.
- W2079410007 cites W2024306318 @default.
- W2079410007 cites W2024520591 @default.
- W2079410007 cites W2028382828 @default.
- W2079410007 cites W2030573603 @default.
- W2079410007 cites W2031032918 @default.
- W2079410007 cites W2033341978 @default.
- W2079410007 cites W2034442000 @default.
- W2079410007 cites W2036902495 @default.
- W2079410007 cites W2039297053 @default.
- W2079410007 cites W2041532598 @default.
- W2079410007 cites W2043718303 @default.
- W2079410007 cites W2045201777 @default.
- W2079410007 cites W2046691249 @default.
- W2079410007 cites W2047143769 @default.
- W2079410007 cites W2048135242 @default.
- W2079410007 cites W2049584647 @default.
- W2079410007 cites W2050936670 @default.
- W2079410007 cites W2054221555 @default.
- W2079410007 cites W2054683873 @default.
- W2079410007 cites W2056684142 @default.
- W2079410007 cites W2056891806 @default.
- W2079410007 cites W2060518035 @default.
- W2079410007 cites W2061111695 @default.
- W2079410007 cites W2061562309 @default.
- W2079410007 cites W2067293720 @default.
- W2079410007 cites W2068605060 @default.
- W2079410007 cites W2070732456 @default.
- W2079410007 cites W2071281521 @default.
- W2079410007 cites W2073723168 @default.
- W2079410007 cites W2074037753 @default.
- W2079410007 cites W2077478539 @default.
- W2079410007 cites W2079724727 @default.
- W2079410007 cites W2080411308 @default.
- W2079410007 cites W2082075917 @default.
- W2079410007 cites W2084882261 @default.
- W2079410007 cites W2087815009 @default.
- W2079410007 cites W2089130049 @default.
- W2079410007 cites W2089475821 @default.
- W2079410007 cites W2093118363 @default.
- W2079410007 cites W2094941511 @default.
- W2079410007 cites W2096484483 @default.
- W2079410007 cites W2099297920 @default.
- W2079410007 cites W2100136475 @default.
- W2079410007 cites W2100170827 @default.
- W2079410007 cites W2100307219 @default.
- W2079410007 cites W2103307139 @default.
- W2079410007 cites W2106201632 @default.
- W2079410007 cites W2106883624 @default.