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- W2079411215 abstract "The LD50 values were utilized to assess the relative rate of absorption of two very poorly soluble drugs. Formulations of these drugs were studied by micronization; addition of surfactant, alkaline or buffering agents, and/or bile salts; coprecipitation; melt or fusion techniques; or granulation with hydrophilic agents. Differences in toxicities were demonstrated from formulations compared to pure drugs by the LD50 method. This study shows that the LD50 is a practical, rapid method of achieving comparative evaluations of drug formulations." @default.
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- W2079411215 title "Evaluation of Drug Formulations Using LD50 Testing in Mice" @default.
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- W2079411215 doi "https://doi.org/10.1002/jps.2600661117" @default.
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