Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079413020> ?p ?o ?g. }
- W2079413020 endingPage "30" @default.
- W2079413020 startingPage "20" @default.
- W2079413020 abstract "Edible mushrooms contain an abundance of immune-enhancing nutrients. Some of these compounds, referred to as biological response modifiers (BRMs), have been used in biological therapies for cancer treatment. We obtained a low-molecular-weight protein fraction (MLP-Fraction) from the fruiting body of the maitake mushroom Grifola frondosa by multiple sequential steps, including ethanol precipitation, DEAE-exchange chromatography, and gel filtration. The effect of the MLP-Fraction on the immune system was determined using normal mice. This resulted in a simultaneous increase in splenocyte proliferation and production of cytokines such as interleukin (IL)-1α, tumor necrosis factor-α, IL-10, IL-12, and interferon (IFN)-γ. The expression levels of IFN-γ and IL-12 in antigen-presenting cells (APCs) and the activation of natural killer (NK) cells, macrophages, and dendritic cells were observed. These results suggest a mechanism in which NK cells are activated through cytokines produced by APCs. We also confirmed the possibility that the MLP-Fraction acts as a BRM using colon-26 carcinoma-bearing mice. This fraction enhanced the production of IL-12 and IFN-γ by splenocytes in tumor-bearing mice and clearly showed an inhibitory effect on tumor cell growth." @default.
- W2079413020 created "2016-06-24" @default.
- W2079413020 creator A5012976671 @default.
- W2079413020 creator A5016734189 @default.
- W2079413020 creator A5055148417 @default.
- W2079413020 creator A5080516823 @default.
- W2079413020 date "2010-02-01" @default.
- W2079413020 modified "2023-09-26" @default.
- W2079413020 title "Potential Antitumor Activity of a Low-Molecular-Weight Protein Fraction from Grifola frondosa Through Enhancement of Cytokine Production" @default.
- W2079413020 cites W1965781918 @default.
- W2079413020 cites W1967384075 @default.
- W2079413020 cites W1969466880 @default.
- W2079413020 cites W1979316085 @default.
- W2079413020 cites W1987653947 @default.
- W2079413020 cites W1988070811 @default.
- W2079413020 cites W1990639778 @default.
- W2079413020 cites W2003555315 @default.
- W2079413020 cites W2009219530 @default.
- W2079413020 cites W2014302440 @default.
- W2079413020 cites W2029359897 @default.
- W2079413020 cites W2033015168 @default.
- W2079413020 cites W2033691547 @default.
- W2079413020 cites W2038794253 @default.
- W2079413020 cites W2048766751 @default.
- W2079413020 cites W2050373409 @default.
- W2079413020 cites W2052791312 @default.
- W2079413020 cites W2053283983 @default.
- W2079413020 cites W2065072311 @default.
- W2079413020 cites W2076053077 @default.
- W2079413020 cites W2078810002 @default.
- W2079413020 cites W2080482077 @default.
- W2079413020 cites W2112480352 @default.
- W2079413020 cites W2118993584 @default.
- W2079413020 cites W2121878520 @default.
- W2079413020 cites W2124921649 @default.
- W2079413020 cites W2143036961 @default.
- W2079413020 cites W2147810177 @default.
- W2079413020 cites W2148049655 @default.
- W2079413020 cites W2156208404 @default.
- W2079413020 cites W2191654227 @default.
- W2079413020 cites W2270398544 @default.
- W2079413020 cites W35753042 @default.
- W2079413020 cites W4243680321 @default.
- W2079413020 doi "https://doi.org/10.1089/jmf.2009.1029" @default.
- W2079413020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20136432" @default.
- W2079413020 hasPublicationYear "2010" @default.
- W2079413020 type Work @default.
- W2079413020 sameAs 2079413020 @default.
- W2079413020 citedByCount "19" @default.
- W2079413020 countsByYear W20794130202012 @default.
- W2079413020 countsByYear W20794130202013 @default.
- W2079413020 countsByYear W20794130202014 @default.
- W2079413020 countsByYear W20794130202015 @default.
- W2079413020 countsByYear W20794130202016 @default.
- W2079413020 countsByYear W20794130202019 @default.
- W2079413020 countsByYear W20794130202020 @default.
- W2079413020 countsByYear W20794130202022 @default.
- W2079413020 countsByYear W20794130202023 @default.
- W2079413020 crossrefType "journal-article" @default.
- W2079413020 hasAuthorship W2079413020A5012976671 @default.
- W2079413020 hasAuthorship W2079413020A5016734189 @default.
- W2079413020 hasAuthorship W2079413020A5055148417 @default.
- W2079413020 hasAuthorship W2079413020A5080516823 @default.
- W2079413020 hasConcept C100817775 @default.
- W2079413020 hasConcept C153911025 @default.
- W2079413020 hasConcept C17991360 @default.
- W2079413020 hasConcept C185592680 @default.
- W2079413020 hasConcept C189976730 @default.
- W2079413020 hasConcept C203014093 @default.
- W2079413020 hasConcept C2776178377 @default.
- W2079413020 hasConcept C2778690821 @default.
- W2079413020 hasConcept C2780108502 @default.
- W2079413020 hasConcept C2780638308 @default.
- W2079413020 hasConcept C55493867 @default.
- W2079413020 hasConcept C74172505 @default.
- W2079413020 hasConcept C86803240 @default.
- W2079413020 hasConcept C8891405 @default.
- W2079413020 hasConceptScore W2079413020C100817775 @default.
- W2079413020 hasConceptScore W2079413020C153911025 @default.
- W2079413020 hasConceptScore W2079413020C17991360 @default.
- W2079413020 hasConceptScore W2079413020C185592680 @default.
- W2079413020 hasConceptScore W2079413020C189976730 @default.
- W2079413020 hasConceptScore W2079413020C203014093 @default.
- W2079413020 hasConceptScore W2079413020C2776178377 @default.
- W2079413020 hasConceptScore W2079413020C2778690821 @default.
- W2079413020 hasConceptScore W2079413020C2780108502 @default.
- W2079413020 hasConceptScore W2079413020C2780638308 @default.
- W2079413020 hasConceptScore W2079413020C55493867 @default.
- W2079413020 hasConceptScore W2079413020C74172505 @default.
- W2079413020 hasConceptScore W2079413020C86803240 @default.
- W2079413020 hasConceptScore W2079413020C8891405 @default.
- W2079413020 hasIssue "1" @default.
- W2079413020 hasLocation W20794130201 @default.
- W2079413020 hasLocation W20794130202 @default.
- W2079413020 hasOpenAccess W2079413020 @default.
- W2079413020 hasPrimaryLocation W20794130201 @default.
- W2079413020 hasRelatedWork W160646284 @default.
- W2079413020 hasRelatedWork W1984364643 @default.