FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079413263> ?p ?o ?g. }

• W2079413263 endingPage "2030" @default.
• W2079413263 startingPage "2023" @default.
• W2079413263 abstract "MDM2 is an important regulator of the p53 tumor suppressor protein. MDM2 inhibits p53 by binding to it, physically blocking its ability to transactivate gene expression, and stimulating its degradation. In cultured cells, mdm2 expression can be regulated by p53. Hence, mdm2 and p53 can interact to form an autoregulatory loop in which p53 activates expression of its own inhibitor. The p53/MDM2 autoregulatory loop has been elucidated within cultured cells; however, regulation of mdm2 expression by p53 has not been demonstrated within intact tissues. Here, we examine the role of p53 in regulating mdm2 expression in vivo in order to test the hypothesis that the p53/MDM2 autoregulatory loop is the mechanism by which low levels of p53 are maintained. We demonstrate that basal expression of mdm2 in murine tissues is p53 independent, even in tissues that express functional p53. Transcription of mdm2 is induced in a p53-dependent manner following gamma irradiation, indicating that p53 regulates mdm2 expression in vivo following a stimulus. The requirement for a stimulus to activate p53-dependent regulation of mdm2 expression in vivo appeared to differ from the situation in early-passage mouse embryo fibroblasts, where mdm2 expression is enhanced by the presence of p53. Analysis of mdm2 expression in intact and dispersed embryos revealed that establishment of mouse embryo fibroblasts in culture induces p53-dependent mdm2expression, suggesting that an unknown stimulus activates p53 function in cultured cells. Together, these results indicate that p53 does not regulate expression of its own inhibitor, except in response to stimuli." @default.
• W2079413263 created "2016-06-24" @default.
• W2079413263 creator A5039907102 @default.
• W2079413263 creator A5042517317 @default.
• W2079413263 date "2000-03-01" @default.
• W2079413263 modified "2023-09-26" @default.
• W2079413263 title "The p53 Tumor Suppressor Protein Does Not Regulate Expression of Its Own Inhibitor, MDM2, Except under Conditions of Stress" @default.
• W2079413263 cites W1491775880 @default.
• W2079413263 cites W1560780012 @default.
• W2079413263 cites W1591281137 @default.
• W2079413263 cites W1949487930 @default.
• W2079413263 cites W1969044026 @default.
• W2079413263 cites W1969972782 @default.
• W2079413263 cites W1973886069 @default.
• W2079413263 cites W1975618936 @default.
• W2079413263 cites W1983751803 @default.
• W2079413263 cites W1985064409 @default.
• W2079413263 cites W1985840237 @default.
• W2079413263 cites W1991494214 @default.
• W2079413263 cites W1993864973 @default.
• W2079413263 cites W1995211857 @default.
• W2079413263 cites W2005701686 @default.
• W2079413263 cites W2011465438 @default.
• W2079413263 cites W2014170738 @default.
• W2079413263 cites W2014938226 @default.
• W2079413263 cites W2016107093 @default.
• W2079413263 cites W2017091696 @default.
• W2079413263 cites W2038173255 @default.
• W2079413263 cites W2039463309 @default.
• W2079413263 cites W2046958356 @default.
• W2079413263 cites W2056530510 @default.
• W2079413263 cites W2059741204 @default.
• W2079413263 cites W2074613316 @default.
• W2079413263 cites W2082399676 @default.
• W2079413263 cites W2082979850 @default.
• W2079413263 cites W2088740611 @default.
• W2079413263 cites W2091151265 @default.
• W2079413263 cites W2099907467 @default.
• W2079413263 cites W2102930268 @default.
• W2079413263 cites W2126679757 @default.
• W2079413263 cites W2149703879 @default.
• W2079413263 cites W2158726042 @default.
• W2079413263 cites W2170494099 @default.
• W2079413263 cites W2184000058 @default.
• W2079413263 doi "https://doi.org/10.1128/mcb.20.6.2023-2030.2000" @default.
• W2079413263 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/110819" @default.
• W2079413263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10688649" @default.
• W2079413263 hasPublicationYear "2000" @default.
• W2079413263 type Work @default.
• W2079413263 sameAs 2079413263 @default.
• W2079413263 citedByCount "81" @default.
• W2079413263 countsByYear W20794132632012 @default.
• W2079413263 countsByYear W20794132632013 @default.
• W2079413263 countsByYear W20794132632014 @default.
• W2079413263 countsByYear W20794132632015 @default.
• W2079413263 countsByYear W20794132632016 @default.
• W2079413263 countsByYear W20794132632017 @default.
• W2079413263 countsByYear W20794132632018 @default.
• W2079413263 countsByYear W20794132632019 @default.
• W2079413263 countsByYear W20794132632020 @default.
• W2079413263 countsByYear W20794132632021 @default.
• W2079413263 countsByYear W20794132632022 @default.
• W2079413263 crossrefType "journal-article" @default.
• W2079413263 hasAuthorship W2079413263A5039907102 @default.
• W2079413263 hasAuthorship W2079413263A5042517317 @default.
• W2079413263 hasBestOaLocation W20794132631 @default.
• W2079413263 hasConcept C153911025 @default.
• W2079413263 hasConcept C2776192174 @default.
• W2079413263 hasConcept C502942594 @default.
• W2079413263 hasConcept C54355233 @default.
• W2079413263 hasConcept C81885089 @default.
• W2079413263 hasConcept C86803240 @default.
• W2079413263 hasConcept C95444343 @default.
• W2079413263 hasConceptScore W2079413263C153911025 @default.
• W2079413263 hasConceptScore W2079413263C2776192174 @default.
• W2079413263 hasConceptScore W2079413263C502942594 @default.
• W2079413263 hasConceptScore W2079413263C54355233 @default.
• W2079413263 hasConceptScore W2079413263C81885089 @default.
• W2079413263 hasConceptScore W2079413263C86803240 @default.
• W2079413263 hasConceptScore W2079413263C95444343 @default.
• W2079413263 hasIssue "6" @default.
• W2079413263 hasLocation W20794132631 @default.
• W2079413263 hasLocation W20794132632 @default.
• W2079413263 hasLocation W20794132633 @default.
• W2079413263 hasOpenAccess W2079413263 @default.
• W2079413263 hasPrimaryLocation W20794132631 @default.
• W2079413263 hasRelatedWork W2144209664 @default.
• W2079413263 hasRelatedWork W2144615015 @default.
• W2079413263 hasRelatedWork W2903620625 @default.
• W2079413263 hasRelatedWork W2950380205 @default.
• W2079413263 hasRelatedWork W2969561067 @default.
• W2079413263 hasRelatedWork W3087486658 @default.
• W2079413263 hasRelatedWork W3148262378 @default.
• W2079413263 hasRelatedWork W3196974467 @default.
• W2079413263 hasRelatedWork W4307910995 @default.
• W2079413263 hasRelatedWork W4308875172 @default.
• W2079413263 hasVolume "20" @default.
• W2079413263 isParatext "false" @default.

• next