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• W2079413382 endingPage "232" @default.
• W2079413382 startingPage "227" @default.
• W2079413382 abstract "In the present study we examined the in vivo effects of glucocorticosteroids and glucagon on the developmental formation of the individual urea cycle enzymes argininosuccinate synthetase, argininosuccinase, and arginase during the late fetal period. In particular, addition of exogenous glucagon caused a rise in argininosuccinase and arginase activities in the livers of rat fetuses at term but not at earlier stages. Glucagon produced a rise in argininosuccinase activity earlier if fetuses were previously treated with cortisol. When fetuses were deprived of corticosteroid (hypophysectomy in utero), glucagon no longer promoted the argninosuccinase activity, indicating that adrenal glucocorticoids are required for normal enhancement of the enzyme activity by glucagon. Dibutyryl cAMP was still effective in hypophysectomized fetuses. Results obtained by injected combinations of inducers indicated that a glucocorticosteroid-glucagon interaction might be involved in the regulation of argininosuccinate synthetase and argininosuccinase. No synergistic action was found on arginase activity in vivo." @default.
• W2079413382 created "2016-06-24" @default.
• W2079413382 creator A5036779225 @default.
• W2079413382 creator A5042989280 @default.
• W2079413382 date "1982-01-01" @default.
• W2079413382 modified "2023-10-15" @default.
• W2079413382 title "Effects of Glucocorticosteroids and Glucagon on Argininosuccinate Synthetase, Argininosuccinase, and Arginase in Fetal Rat Liver*" @default.
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• W2079413382 doi "https://doi.org/10.1210/endo-110-1-227" @default.
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