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• W2079413441 abstract "Previous studies showed that the serum- and glucocorticoid-inducible kinase ( sgk ) gene plays an important role in long-term memory formation. The present study further examined the role of SGK in long-term potentiation (LTP). The dominant-negative mutant of sgk, SGKS422A, was used to inactivate SGK. Results revealed a time-dependent increase in SGK phosphorylation after tetanization with a significant effect observed 3 h and 5 h later. Transfection of SGKS422A impaired the expression, but not the induction, of LTP. Furthermore, the constitutively active sgk, SGKS422D, up-regulated postsynaptic density-95 expression in the hippocampus. These results together support the role of SGK in neuronal plasticity." @default.
• W2079413441 created "2016-06-24" @default.
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• W2079413441 date "2006-03-01" @default.
• W2079413441 modified "2023-09-25" @default.
• W2079413441 title "SGK protein kinase facilitates the expression of long-term potentiation in hippocampal neurons" @default.
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• W2079413441 doi "https://doi.org/10.1101/lm.179206" @default.
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