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• W2079415761 abstract "Purpose.: To evaluate macular focal cone ERG (fERG) as a tool for reliable and early detection of central retinal function decay in cone–rod dystrophy (CRD). Methods.: A retrospective study of the time course of fERG amplitude and its relation to visual acuity alterations was performed in 47 CRD patients followed yearly for 6.0 ± 3.1 years. Macular focal cone ERG was evoked by a flickering uniform red field overlaying the central 18° of visual field. Results.: Macular focal cone ERG follow-up allowed a clear-cut identification of CRD patients as stationary or progressive, in agreement with visual acuity follow-up. In all progressive patients, fERG declined whenever visual acuity declined, and—in 50% of the cases—fERG loss anticipated acuity loss of several years. Conclusions.: Macular focal cone ERG represents a sensitive assay to detect, categorize, and follow the progression of central retinal dysfunction in CRD. Its use as a diagnostic tool in CRD may help anticipate, for an individual patient, the likelihood and rate of further disease progression before visual acuity loss has occurred." @default.
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• W2079415761 date "2013-10-09" @default.
• W2079415761 modified "2023-10-14" @default.
• W2079415761 title "Early Detection of Central Visual Function Decline in Cone–Rod Dystrophy by the Use of Macular Focal Cone Electroretinogram" @default.
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• W2079415761 doi "https://doi.org/10.1167/iovs.13-12676" @default.
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