Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079416223> ?p ?o ?g. }
- W2079416223 endingPage "28" @default.
- W2079416223 startingPage "22" @default.
- W2079416223 abstract "The accumulation of misfolded proteins in insoluble aggregates within the neuronal cytoplasm is one of the common pathological hallmarks of most adult-onset human neurodegenerative diseases. The clearance of these misfolded proteins may represent a promising therapeutic strategy in these diseases. The two main routes for intracellular protein degradation are the ubiquitin-proteasome and the autophagy-lysosome pathways. In this review, we will focus on the autophagic pathway, by providing some examples of how impairment at different steps in this degradation pathway is related to different neurodegenerative diseases. We will also consider that upregulating autophagy may be useful in the treatment of some of these diseases. Finally, we discuss how antioxidants, which have been considered to be beneficial in neurodegenerative diseases, can block autophagy, thus potentially compromising their therapeutic potential." @default.
- W2079416223 created "2016-06-24" @default.
- W2079416223 creator A5000014285 @default.
- W2079416223 creator A5008236816 @default.
- W2079416223 creator A5068058486 @default.
- W2079416223 creator A5072696557 @default.
- W2079416223 date "2012-11-01" @default.
- W2079416223 modified "2023-09-27" @default.
- W2079416223 title "Autophagy and misfolded proteins in neurodegeneration" @default.
- W2079416223 cites W118722484 @default.
- W2079416223 cites W1490798921 @default.
- W2079416223 cites W1538471627 @default.
- W2079416223 cites W1562156325 @default.
- W2079416223 cites W1584056801 @default.
- W2079416223 cites W1643149493 @default.
- W2079416223 cites W1966227354 @default.
- W2079416223 cites W1968265417 @default.
- W2079416223 cites W1969342645 @default.
- W2079416223 cites W1975915706 @default.
- W2079416223 cites W1976064867 @default.
- W2079416223 cites W1983287446 @default.
- W2079416223 cites W1988044873 @default.
- W2079416223 cites W1998354357 @default.
- W2079416223 cites W2001591494 @default.
- W2079416223 cites W2002636911 @default.
- W2079416223 cites W2004219186 @default.
- W2079416223 cites W2005997790 @default.
- W2079416223 cites W2007240769 @default.
- W2079416223 cites W2008274598 @default.
- W2079416223 cites W2008417639 @default.
- W2079416223 cites W2010559308 @default.
- W2079416223 cites W2011649561 @default.
- W2079416223 cites W2014734622 @default.
- W2079416223 cites W2014918593 @default.
- W2079416223 cites W2018636808 @default.
- W2079416223 cites W2022812113 @default.
- W2079416223 cites W2025176940 @default.
- W2079416223 cites W2025714022 @default.
- W2079416223 cites W2026398863 @default.
- W2079416223 cites W2027785297 @default.
- W2079416223 cites W2032377673 @default.
- W2079416223 cites W2034183549 @default.
- W2079416223 cites W2038164359 @default.
- W2079416223 cites W2039525732 @default.
- W2079416223 cites W2045062972 @default.
- W2079416223 cites W2054810866 @default.
- W2079416223 cites W2057764483 @default.
- W2079416223 cites W2060579362 @default.
- W2079416223 cites W2062686313 @default.
- W2079416223 cites W2065247147 @default.
- W2079416223 cites W2066754298 @default.
- W2079416223 cites W2067692987 @default.
- W2079416223 cites W2069104646 @default.
- W2079416223 cites W2076107153 @default.
- W2079416223 cites W2077731318 @default.
- W2079416223 cites W2078527512 @default.
- W2079416223 cites W2082229119 @default.
- W2079416223 cites W2082637970 @default.
- W2079416223 cites W2083885037 @default.
- W2079416223 cites W2088198588 @default.
- W2079416223 cites W2098077028 @default.
- W2079416223 cites W2098985594 @default.
- W2079416223 cites W2103275390 @default.
- W2079416223 cites W2103377481 @default.
- W2079416223 cites W2104850613 @default.
- W2079416223 cites W2108086395 @default.
- W2079416223 cites W2110491903 @default.
- W2079416223 cites W2111567059 @default.
- W2079416223 cites W2112329697 @default.
- W2079416223 cites W2113432343 @default.
- W2079416223 cites W2115632183 @default.
- W2079416223 cites W2116766274 @default.
- W2079416223 cites W2121104406 @default.
- W2079416223 cites W2121429373 @default.
- W2079416223 cites W2124644922 @default.
- W2079416223 cites W2128537698 @default.
- W2079416223 cites W2129321855 @default.
- W2079416223 cites W2129447571 @default.
- W2079416223 cites W2130196517 @default.
- W2079416223 cites W2130498948 @default.
- W2079416223 cites W2132763961 @default.
- W2079416223 cites W2137498550 @default.
- W2079416223 cites W2139285220 @default.
- W2079416223 cites W2142044474 @default.
- W2079416223 cites W2142047537 @default.
- W2079416223 cites W2144718635 @default.
- W2079416223 cites W2146415848 @default.
- W2079416223 cites W2147729862 @default.
- W2079416223 cites W2147799082 @default.
- W2079416223 cites W2155613422 @default.
- W2079416223 cites W2156144699 @default.
- W2079416223 cites W2157535220 @default.
- W2079416223 cites W2157766835 @default.
- W2079416223 cites W2157940538 @default.
- W2079416223 cites W2158264749 @default.
- W2079416223 cites W2160571070 @default.
- W2079416223 cites W2160579896 @default.
- W2079416223 cites W2161803468 @default.