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- W2079416900 abstract "Recently, a number of nuclear receptors have been identified as key regulators of cholesterol homeostasis. Two of these, liver X receptor alpha (LXRα) (NR1H3) [1] and ubiquitous receptor (UR) (NR1H2) [1], appear to be involved in cholesterol reverse transport and disposal. LXRα null gene mice fail to adapt metabolically to high-cholesterol diets. We have recently shown that some 6α-hydroxylated bile acid analogs are selective activators of LXRα. In this report, we show that these orally administered LXRα agonists have an overall hypolipidemic effect in hypercholesterolemic rats, mice and hamsters, which indicates that in these animal models, endogenous LXRα agonist is a limiting factor for induction of cholesterol disposal. Furthermore, in animals, these 6α-hydroxylated bile acid analogs exhibit a unique pharmacokinetic profile and do not increase the serum triglyceride level; therefore, they may represent a novel class of therapeutic agents for cholesterol management." @default.
- W2079416900 created "2016-06-24" @default.
- W2079416900 creator A5034961712 @default.
- W2079416900 creator A5091724295 @default.
- W2079416900 date "2001-09-01" @default.
- W2079416900 modified "2023-09-30" @default.
- W2079416900 title "Hypolipidemic effects of selective liver X receptor alpha agonists" @default.
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- W2079416900 doi "https://doi.org/10.1016/s0039-128x(01)00132-5" @default.
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