FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079425193> ?p ?o ?g. }

• W2079425193 abstract "Restorative proctocolectomy is the procedure of choice for patients who require surgical treatment for ulcerative colitis. The diseased colon and rectum are removed and a pelvic reservoir (pouch) is constructed from healthy ileum and anastomosed to the anal sphincter (1). A permanent ileostomy is thus avoided and anal continence is preserved. The patients' quality of life is good (2). The ileal reservoir may become inflamed. Although chronic inflammatory changes are almost universal and asymptomatic, acute inflammation with mucosal ulceration results in the clinical condition of 'acute pouchifis'. It affects 10-20% of patients (3) and is characterised by intermittent episodes of increased frequency of urgent bowel action, loose, bloodstained stools, malaise and lower abdominal discomfort. Extraintesfinal manifestations, as seen in colitics, may occur at the same time as relapses of pouchitis (4). Focal erythema, ulceration and contact bleeding are seen and histologically there is a marked acute inflammatory infiltrate with villous atrophy, crypt abscesses and superficial ulceration. The condition shares many similarities with ulcerative colitis and, although the aefiology of both conditions remains undetermined, it is likely that they are closely linked. Clinical and experimental studies suggest that pouchifis represents a novel recurrence of chronic ulcerative colitis in pelvic ileal reservoirs (5). Villous atrophy is accompanied by a neutrophil and eosinophil inflammatory response with a less marked ingress of mononuclear inflammatory cells and Paneth cell hyperplasia. The mucosa partially develops a colonic phenotype (6) with a significant increase in sulphomucin-containing goblet cells. Chronic ulcerative colitis and pouchitis are likely to share similar aefiological factors (7). Pouchitis is very rare after restorative proctocolectomy for non-colitic indications such as familial adenomatous polyposis (FAP) and it has been suggested that the occasional well documented case of pouchifis in a patient with FAP (8) may represent coexistence of FAP and ulcerative colitis in the same patient (9). As the condition is frequently responsive to metronidazole, a bacterial cause has been suggested. However, no differences in faecal flora have been demonstrated between patients with and without acute pouchitis. Inefficient evacuation of the pouch at defaecation may result in stasis and an increase in the proportion of anaerobes to aerobes. No correlation exists, however, between numbers of specific bacteria or the efficiency of evacuation of the pouch and the severity of pouchitis (10). Alternative explanations have included mucosal ischaemia, mucosal prolapse and Crohn's disease but it is likely that these are conditions which produce similar features to those seen in acute pouchitis rather than being the cause of the condition. We postulate that both ulcerative colitis and acute pouchitis may be a manifestation of enterocyte fuel deficiency." @default.
• W2079425193 created "2016-06-24" @default.
• W2079425193 creator A5007654270 @default.
• W2079425193 creator A5012758241 @default.
• W2079425193 date "1995-02-01" @default.
• W2079425193 modified "2023-09-27" @default.
• W2079425193 title "Pouchitis, colitis and deficiencies of fuel" @default.
• W2079425193 cites W1506819190 @default.
• W2079425193 cites W1511049584 @default.
• W2079425193 cites W1531062343 @default.
• W2079425193 cites W1570526968 @default.
• W2079425193 cites W1576218825 @default.
• W2079425193 cites W1592254411 @default.
• W2079425193 cites W1696136056 @default.
• W2079425193 cites W1784066345 @default.
• W2079425193 cites W1800141310 @default.
• W2079425193 cites W1968184715 @default.
• W2079425193 cites W1975469885 @default.
• W2079425193 cites W1983671706 @default.
• W2079425193 cites W1983877797 @default.
• W2079425193 cites W1985766240 @default.
• W2079425193 cites W1988724458 @default.
• W2079425193 cites W1992081854 @default.
• W2079425193 cites W1994604595 @default.
• W2079425193 cites W2007838388 @default.
• W2079425193 cites W2008378217 @default.
• W2079425193 cites W2010229349 @default.
• W2079425193 cites W2013645087 @default.
• W2079425193 cites W2018861313 @default.
• W2079425193 cites W2052896018 @default.
• W2079425193 cites W2057965062 @default.
• W2079425193 cites W2064909225 @default.
• W2079425193 cites W2071106723 @default.
• W2079425193 cites W2071799444 @default.
• W2079425193 cites W2084660643 @default.
• W2079425193 cites W2102344777 @default.
• W2079425193 cites W2139232831 @default.
• W2079425193 cites W2292459909 @default.
• W2079425193 cites W2321654132 @default.
• W2079425193 cites W2322126628 @default.
• W2079425193 cites W2428733455 @default.
• W2079425193 cites W2750169099 @default.
• W2079425193 cites W1995157483 @default.
• W2079425193 doi "https://doi.org/10.1016/s0261-5614(06)80004-x" @default.
• W2079425193 hasPublicationYear "1995" @default.
• W2079425193 type Work @default.
• W2079425193 sameAs 2079425193 @default.
• W2079425193 citedByCount "3" @default.
• W2079425193 crossrefType "journal-article" @default.
• W2079425193 hasAuthorship W2079425193A5007654270 @default.
• W2079425193 hasAuthorship W2079425193A5012758241 @default.
• W2079425193 hasConcept C126322002 @default.
• W2079425193 hasConcept C141071460 @default.
• W2079425193 hasConcept C142724271 @default.
• W2079425193 hasConcept C2775862500 @default.
• W2079425193 hasConcept C2777077811 @default.
• W2079425193 hasConcept C2778773085 @default.
• W2079425193 hasConcept C2779134260 @default.
• W2079425193 hasConcept C2779280984 @default.
• W2079425193 hasConcept C2779454807 @default.
• W2079425193 hasConcept C2780101441 @default.
• W2079425193 hasConcept C2780349322 @default.
• W2079425193 hasConcept C2780479503 @default.
• W2079425193 hasConcept C2780941987 @default.
• W2079425193 hasConcept C2781074409 @default.
• W2079425193 hasConcept C2993432164 @default.
• W2079425193 hasConcept C71924100 @default.
• W2079425193 hasConcept C90924648 @default.
• W2079425193 hasConceptScore W2079425193C126322002 @default.
• W2079425193 hasConceptScore W2079425193C141071460 @default.
• W2079425193 hasConceptScore W2079425193C142724271 @default.
• W2079425193 hasConceptScore W2079425193C2775862500 @default.
• W2079425193 hasConceptScore W2079425193C2777077811 @default.
• W2079425193 hasConceptScore W2079425193C2778773085 @default.
• W2079425193 hasConceptScore W2079425193C2779134260 @default.
• W2079425193 hasConceptScore W2079425193C2779280984 @default.
• W2079425193 hasConceptScore W2079425193C2779454807 @default.
• W2079425193 hasConceptScore W2079425193C2780101441 @default.
• W2079425193 hasConceptScore W2079425193C2780349322 @default.
• W2079425193 hasConceptScore W2079425193C2780479503 @default.
• W2079425193 hasConceptScore W2079425193C2780941987 @default.
• W2079425193 hasConceptScore W2079425193C2781074409 @default.
• W2079425193 hasConceptScore W2079425193C2993432164 @default.
• W2079425193 hasConceptScore W2079425193C71924100 @default.
• W2079425193 hasConceptScore W2079425193C90924648 @default.
• W2079425193 hasLocation W20794251931 @default.
• W2079425193 hasOpenAccess W2079425193 @default.
• W2079425193 hasPrimaryLocation W20794251931 @default.
• W2079425193 hasRelatedWork W120968327 @default.
• W2079425193 hasRelatedWork W131801356 @default.
• W2079425193 hasRelatedWork W1983777195 @default.
• W2079425193 hasRelatedWork W2039593249 @default.
• W2079425193 hasRelatedWork W2045377222 @default.
• W2079425193 hasRelatedWork W2047473928 @default.
• W2079425193 hasRelatedWork W2062132000 @default.
• W2079425193 hasRelatedWork W2108826619 @default.
• W2079425193 hasRelatedWork W2149993196 @default.
• W2079425193 hasRelatedWork W2321968209 @default.
• W2079425193 hasRelatedWork W2342019718 @default.
• W2079425193 hasRelatedWork W2407745819 @default.

• next