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• W2079426997 abstract "Acute severe colitis fortunately occurs in only a minority of patients with inflammatory bowel disease (IBD), but its onset heralds a difficult disease course. With the institution of the ‘Oxford regimen’ several decades ago, the mortality of acute severe ulcerative colitis (UC) has fallen to 2% or less in high-volume centres [ 1 Travis S.P. Farrant J.M. Ricketts C. Nolan D.J. Mortensen N.M. Kettlewell M.G. et al. Predicting outcome in severe ulcerative colitis. Gut. 1996; 38: 905-910 Crossref PubMed Scopus (589) Google Scholar , 2 Carbonnel F. Gargouri D. Lemann M. Beaugerie L. Cattan S. Cosnes J. et al. Predictive factors of outcome of intensive intravenous treatment for attacks of ulcerative colitis. Aliment. Pharmacol. Ther. 2000; 14: 273-279 Crossref PubMed Scopus (115) Google Scholar , 3 Ho G.T. Mowat C. Goddard C.J.R. Fennell J.M. Shah N.B. Prescott R.J. et al. Predicting the outcome of severe ulcerative colitis: development of a novel risk score to aid early selection of patients for second-line medical therapy or surgery. Aliment. Pharmacol. Ther. 2004; 19: 1079-1087 Crossref PubMed Scopus (209) Google Scholar ]. The two main pillars of this approach were administration of intravenous corticosteroids and a willingness to proceed with colectomy if the patient was not clinically improving within 5–10 days of admission. More recently, intravenous cyclosporine for steroid-refractory disease has been added to the medical armamentarium at some referral centres, slightly altering the therapeutic approach [ [4] Loftus C.G. Loftus Jr., E.V. Sandborn W.J. Cyclosporin for refractory ulcerative colitis. Gut. 2003; 52: 172-173 Crossref PubMed Scopus (39) Google Scholar ]. Nevertheless, colectomy rates in recent case series of acute severe colitis still range from 29 to 43% [ 1 Travis S.P. Farrant J.M. Ricketts C. Nolan D.J. Mortensen N.M. Kettlewell M.G. et al. Predicting outcome in severe ulcerative colitis. Gut. 1996; 38: 905-910 Crossref PubMed Scopus (589) Google Scholar , 2 Carbonnel F. Gargouri D. Lemann M. Beaugerie L. Cattan S. Cosnes J. et al. Predictive factors of outcome of intensive intravenous treatment for attacks of ulcerative colitis. Aliment. Pharmacol. Ther. 2000; 14: 273-279 Crossref PubMed Scopus (115) Google Scholar , 3 Ho G.T. Mowat C. Goddard C.J.R. Fennell J.M. Shah N.B. Prescott R.J. et al. Predicting the outcome of severe ulcerative colitis: development of a novel risk score to aid early selection of patients for second-line medical therapy or surgery. Aliment. Pharmacol. Ther. 2004; 19: 1079-1087 Crossref PubMed Scopus (209) Google Scholar ]. Furthermore, many of the patients fortunate enough to avoid colectomy may experience medication side-effects." @default.
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• W2079426997 title "Hunting for the owl's eye in acute severe colitis: the role of cytomegalovirus" @default.
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