FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079427367> ?p ?o ?g. }

• W2079427367 endingPage "e2" @default.
• W2079427367 startingPage "e2" @default.
• W2079427367 abstract "Drug addiction is a serious worldwide problem with strong genetic and environmental influences. Different technologies have revealed a variety of genes and pathways underlying addiction; however, each individual technology can be biased and incomplete. We integrated 2,343 items of evidence from peer-reviewed publications between 1976 and 2006 linking genes and chromosome regions to addiction by single-gene strategies, microrray, proteomics, or genetic studies. We identified 1,500 human addiction-related genes and developed KARG (http://karg.cbi.pku.edu.cn), the first molecular database for addiction-related genes with extensive annotations and a friendly Web interface. We then performed a meta-analysis of 396 genes that were supported by two or more independent items of evidence to identify 18 molecular pathways that were statistically significantly enriched, covering both upstream signaling events and downstream effects. Five molecular pathways significantly enriched for all four different types of addictive drugs were identified as common pathways which may underlie shared rewarding and addictive actions, including two new ones, GnRH signaling pathway and gap junction. We connected the common pathways into a hypothetical common molecular network for addiction. We observed that fast and slow positive feedback loops were interlinked through CAMKII, which may provide clues to explain some of the irreversible features of addiction." @default.
• W2079427367 created "2016-06-24" @default.
• W2079427367 creator A5010889555 @default.
• W2079427367 creator A5022243401 @default.
• W2079427367 creator A5033594244 @default.
• W2079427367 date "2008-01-04" @default.
• W2079427367 modified "2023-09-29" @default.
• W2079427367 title "Genes and (Common) Pathways Underlying Drug Addiction" @default.
• W2079427367 cites W1547308539 @default.
• W2079427367 cites W1911421926 @default.
• W2079427367 cites W1969628539 @default.
• W2079427367 cites W1973768615 @default.
• W2079427367 cites W1981918245 @default.
• W2079427367 cites W1984363963 @default.
• W2079427367 cites W1988182239 @default.
• W2079427367 cites W1990027430 @default.
• W2079427367 cites W1990270083 @default.
• W2079427367 cites W1990405961 @default.
• W2079427367 cites W1994882032 @default.
• W2079427367 cites W2003781010 @default.
• W2079427367 cites W2010192358 @default.
• W2079427367 cites W2014549178 @default.
• W2079427367 cites W2021658351 @default.
• W2079427367 cites W2022419428 @default.
• W2079427367 cites W2033670390 @default.
• W2079427367 cites W2033772281 @default.
• W2079427367 cites W2043649737 @default.
• W2079427367 cites W2045234988 @default.
• W2079427367 cites W2049222254 @default.
• W2079427367 cites W2049336663 @default.
• W2079427367 cites W2049796382 @default.
• W2079427367 cites W2053989396 @default.
• W2079427367 cites W2055043387 @default.
• W2079427367 cites W2057015734 @default.
• W2079427367 cites W2058374068 @default.
• W2079427367 cites W2072159031 @default.
• W2079427367 cites W2088839435 @default.
• W2079427367 cites W2091064369 @default.
• W2079427367 cites W2092206993 @default.
• W2079427367 cites W2092558173 @default.
• W2079427367 cites W2096525273 @default.
• W2079427367 cites W2103017472 @default.
• W2079427367 cites W2105106534 @default.
• W2079427367 cites W2111627817 @default.
• W2079427367 cites W2113755074 @default.
• W2079427367 cites W2116504386 @default.
• W2079427367 cites W2119195082 @default.
• W2079427367 cites W2120935357 @default.
• W2079427367 cites W2125808663 @default.
• W2079427367 cites W2126393500 @default.
• W2079427367 cites W2128103152 @default.
• W2079427367 cites W2130766562 @default.
• W2079427367 cites W2152653671 @default.
• W2079427367 cites W2157387402 @default.
• W2079427367 cites W2165674132 @default.
• W2079427367 cites W2169905651 @default.
• W2079427367 cites W4236324471 @default.
• W2079427367 cites W4247666721 @default.
• W2079427367 doi "https://doi.org/10.1371/journal.pcbi.0040002" @default.
• W2079427367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2174978" @default.
• W2079427367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18179280" @default.
• W2079427367 hasPublicationYear "2008" @default.
• W2079427367 type Work @default.
• W2079427367 sameAs 2079427367 @default.
• W2079427367 citedByCount "199" @default.
• W2079427367 countsByYear W20794273672012 @default.
• W2079427367 countsByYear W20794273672013 @default.
• W2079427367 countsByYear W20794273672014 @default.
• W2079427367 countsByYear W20794273672015 @default.
• W2079427367 countsByYear W20794273672016 @default.
• W2079427367 countsByYear W20794273672017 @default.
• W2079427367 countsByYear W20794273672018 @default.
• W2079427367 countsByYear W20794273672019 @default.
• W2079427367 countsByYear W20794273672020 @default.
• W2079427367 countsByYear W20794273672021 @default.
• W2079427367 countsByYear W20794273672022 @default.
• W2079427367 countsByYear W20794273672023 @default.
• W2079427367 crossrefType "journal-article" @default.
• W2079427367 hasAuthorship W2079427367A5010889555 @default.
• W2079427367 hasAuthorship W2079427367A5022243401 @default.
• W2079427367 hasAuthorship W2079427367A5033594244 @default.
• W2079427367 hasBestOaLocation W20794273671 @default.
• W2079427367 hasConcept C104317684 @default.
• W2079427367 hasConcept C169760540 @default.
• W2079427367 hasConcept C48856860 @default.
• W2079427367 hasConcept C54355233 @default.
• W2079427367 hasConcept C60644358 @default.
• W2079427367 hasConcept C70721500 @default.
• W2079427367 hasConcept C86803240 @default.
• W2079427367 hasConceptScore W2079427367C104317684 @default.
• W2079427367 hasConceptScore W2079427367C169760540 @default.
• W2079427367 hasConceptScore W2079427367C48856860 @default.
• W2079427367 hasConceptScore W2079427367C54355233 @default.
• W2079427367 hasConceptScore W2079427367C60644358 @default.
• W2079427367 hasConceptScore W2079427367C70721500 @default.
• W2079427367 hasConceptScore W2079427367C86803240 @default.
• W2079427367 hasIssue "1" @default.
• W2079427367 hasLocation W20794273671 @default.

• next