FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079427385> ?p ?o ?g. }

• W2079427385 endingPage "744" @default.
• W2079427385 startingPage "740" @default.
• W2079427385 abstract "Olgoxin pharmacokinetics were studied in 16 obese (mean ± SD weight, 100.2 ± 36.8 kg) and 13 control (64.6 ± 10.5 kg) subjects. all subjects had normal renal function and no other coexisting disease. After administration of 0.75 mg digoxin by intravenous intusion, multiple plasma samples obtained over the 96 hours following infusion were analyzed for digoxin concentration by radloimmunoassay. Pharmacokinetic parameters were determined by weighted iterative nonlinear least squares regression analysis. Elimination half-life (t12) was not different between obese and control groups (35.6 ± 10.5 vs 41.2 ± 16.7 hours). Absolute volume of distribution (Vd) also was not different (981 ± 301 vs 937 ± 397 liters), nor was total clearance of digoxin (328 ± 82 vs 278 ± 87 ml/min). Elimination t12 was significantly negatively correlated with clearance among all subjects (r = −0.46; p < 0.01). Using percent ideal body weight (IBW) as a measure of obesity, no correlation was found between percent IBW and Vd (r = 0.03). Thus digoxin is simllarly distributed into IBW in obese and normal weight subjects, and there is no significant distribution of digoxin into excese body weight over IBW. In addition, there is no difference in total metabolic clearance or elimination half-life between obese and control subjects. Digoxin loading and maintenance dosage should be calculated on the basis of IBW, which reflects lean body mass, rather than TBW, which reflects adipose tissue weight in addition to lean body mass." @default.
• W2079427385 created "2016-06-24" @default.
• W2079427385 creator A5019594950 @default.
• W2079427385 creator A5028460883 @default.
• W2079427385 creator A5087737186 @default.
• W2079427385 date "1981-10-01" @default.
• W2079427385 modified "2023-10-10" @default.
• W2079427385 title "Digoxin disposition in obesity: Clinical pharmacokinetic investigation" @default.
• W2079427385 cites W102728013 @default.
• W2079427385 cites W150877756 @default.
• W2079427385 cites W1979955365 @default.
• W2079427385 cites W2007922707 @default.
• W2079427385 cites W2020709519 @default.
• W2079427385 cites W2029509299 @default.
• W2079427385 cites W205227533 @default.
• W2079427385 cites W2058808870 @default.
• W2079427385 cites W2061150625 @default.
• W2079427385 cites W2061513865 @default.
• W2079427385 cites W2070842387 @default.
• W2079427385 cites W2074743488 @default.
• W2079427385 cites W2079646286 @default.
• W2079427385 cites W2087070363 @default.
• W2079427385 cites W2401380019 @default.
• W2079427385 cites W2413244612 @default.
• W2079427385 cites W2414637215 @default.
• W2079427385 cites W2419309985 @default.
• W2079427385 cites W2438480540 @default.
• W2079427385 cites W4247640992 @default.
• W2079427385 doi "https://doi.org/10.1016/0002-8703(81)90100-9" @default.
• W2079427385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7282520" @default.
• W2079427385 hasPublicationYear "1981" @default.
• W2079427385 type Work @default.
• W2079427385 sameAs 2079427385 @default.
• W2079427385 citedByCount "83" @default.
• W2079427385 countsByYear W20794273852012 @default.
• W2079427385 countsByYear W20794273852013 @default.
• W2079427385 countsByYear W20794273852014 @default.
• W2079427385 countsByYear W20794273852015 @default.
• W2079427385 countsByYear W20794273852017 @default.
• W2079427385 countsByYear W20794273852018 @default.
• W2079427385 countsByYear W20794273852019 @default.
• W2079427385 countsByYear W20794273852020 @default.
• W2079427385 countsByYear W20794273852021 @default.
• W2079427385 countsByYear W20794273852022 @default.
• W2079427385 countsByYear W20794273852023 @default.
• W2079427385 crossrefType "journal-article" @default.
• W2079427385 hasAuthorship W2079427385A5019594950 @default.
• W2079427385 hasAuthorship W2079427385A5028460883 @default.
• W2079427385 hasAuthorship W2079427385A5087737186 @default.
• W2079427385 hasConcept C110121322 @default.
• W2079427385 hasConcept C112705442 @default.
• W2079427385 hasConcept C120863210 @default.
• W2079427385 hasConcept C126322002 @default.
• W2079427385 hasConcept C134018914 @default.
• W2079427385 hasConcept C134306372 @default.
• W2079427385 hasConcept C139254425 @default.
• W2079427385 hasConcept C147583825 @default.
• W2079427385 hasConcept C159641895 @default.
• W2079427385 hasConcept C171089720 @default.
• W2079427385 hasConcept C2777707475 @default.
• W2079427385 hasConcept C2778198053 @default.
• W2079427385 hasConcept C33923547 @default.
• W2079427385 hasConcept C511355011 @default.
• W2079427385 hasConcept C71924100 @default.
• W2079427385 hasConcept C84029825 @default.
• W2079427385 hasConceptScore W2079427385C110121322 @default.
• W2079427385 hasConceptScore W2079427385C112705442 @default.
• W2079427385 hasConceptScore W2079427385C120863210 @default.
• W2079427385 hasConceptScore W2079427385C126322002 @default.
• W2079427385 hasConceptScore W2079427385C134018914 @default.
• W2079427385 hasConceptScore W2079427385C134306372 @default.
• W2079427385 hasConceptScore W2079427385C139254425 @default.
• W2079427385 hasConceptScore W2079427385C147583825 @default.
• W2079427385 hasConceptScore W2079427385C159641895 @default.
• W2079427385 hasConceptScore W2079427385C171089720 @default.
• W2079427385 hasConceptScore W2079427385C2777707475 @default.
• W2079427385 hasConceptScore W2079427385C2778198053 @default.
• W2079427385 hasConceptScore W2079427385C33923547 @default.
• W2079427385 hasConceptScore W2079427385C511355011 @default.
• W2079427385 hasConceptScore W2079427385C71924100 @default.
• W2079427385 hasConceptScore W2079427385C84029825 @default.
• W2079427385 hasIssue "4" @default.
• W2079427385 hasLocation W20794273851 @default.
• W2079427385 hasLocation W20794273852 @default.
• W2079427385 hasOpenAccess W2079427385 @default.
• W2079427385 hasPrimaryLocation W20794273851 @default.
• W2079427385 hasRelatedWork W1508788540 @default.
• W2079427385 hasRelatedWork W2000162860 @default.
• W2079427385 hasRelatedWork W2002698569 @default.
• W2079427385 hasRelatedWork W2058340092 @default.
• W2079427385 hasRelatedWork W2068673501 @default.
• W2079427385 hasRelatedWork W2088883133 @default.
• W2079427385 hasRelatedWork W2410349813 @default.
• W2079427385 hasRelatedWork W2414168851 @default.
• W2079427385 hasRelatedWork W2429926177 @default.
• W2079427385 hasRelatedWork W4239185371 @default.
• W2079427385 hasVolume "102" @default.
• W2079427385 isParatext "false" @default.

• next